Coordinator of Research Team
Name Massimo Mannelli
Position Full Professor in Endocrinology, Director of Endocrinology SOD dell’Azienda Ospedaliero-Universitaria Careggi
Name of Research Team/Laboratory Adrenal Gland Lab
telephone number 055 2758414
Brief biographical sketch of the Coordinator
Born in Florence, April 19, 1948
Degrees and Positions:
1967 High School Degree in Florence
1973 MD Degree at the University of Florence, Magna cum Laude
1974 Certificate of Proficiency in English, University of Michigan, English Language Institute
1976 Postgraduate Degree in Cardiology, University of Florence, Magna cum Laude
1979 Postgraduate Degree in Endocrinology, University of Florence, Magna cum Laude
1974-1984 Assistant attending at the Laboratory Service, Endocrinology Unit
1984-1992 Assistant attending at the Endocrine Clinical Service, Endocrinology Unit
1992 to 2004 Associate Professor in Endocrinology, Department of Clinical
Pathophysiology, University of Florence
2004 to present Full Professor in Endocrinology, Department of Experimental and Clinical
Biomedical Sciences, University of Florence
1982 to present: at the Post-graduate School of Endocrinology, University of Florence.
1987-2002: at the post-graduate School of Nuclear Medicine, University of Florence.
1992 to present: at the Student School of Medicine, University of Florence
1995-2001: Member of the Teaching Committee of the Italian Endocrine Society
2006 to present: at the Student School of Physical Sciences, University of Florence
2010 to 2015: Director of the Post-graduate School of Endocrinology and Metabolism,
University of Florence.
1987 Scientific Secretary of the International Meeting on “The Peripheral Dopaminergic System. Its role in cardiovascular homeostasis”, Florence, Italy
1992 - 1995 Member of the Scientific Committee of the Italian Endocrine Society
1998 - 1999 Coordinator of the Pheochromocytoma Study Group of the Italian Endocrine Society
2000- 2004 Associate Editor of the Journal ²L’Endocrinologo².
2000- 2003 Member of the Board of the Italian Endocrine Society
2003-2005 Coordinator of the Scientific Committee of the Italian Endocrine Society
2003 -2012 Member of the Steering Committee of the ENS@T (European Network for the
Study of the Adrenal Tumors)
2005 -2007 Coordinator of the Study Group of the Genetics of Pheochromocytoma in Italy for
the Italian Endocrine Society
2005 Member of the International Organizing Committee of the 1st Intern. Symposium on Pheochromocytoma, NIH, Washington, October 2005
2005-present Supervisor of the Service for the Genetic Analyses of pheochromocytoma/paraganglioma, Endocrine Laboratory, University Hospital Careggi, Florence.
2007 Member of the International Organizing Committee of the 2nd Intern. Symposium on Pheochromocytoma, Cambridge, UK, September 2008
2007 Organization of the 6th ENS@T Scientific Meeting, Florence, Nov. 2007
2008 Recipient of the 39th Helen and Payne Whitney Lecturship in Medicine, “ Clinical
and genetic aspects of Pheochromocytoma”. North Shore Long Island Jewish
Medical Center, North Shore University Hospital, NY
2009 Member of the MPGE (Malignant Pheochromocytoma Group Expert), New York,
2009 Member of the Scientific Board of the International Symposium on Adrenal
Tumors, Padova, September 2009
2009-present Member of the Executive Committee of the Pheochromocytoma Research Support Organization (PRESSOR http://www.pressor.org).
2009 Reviewer for the Academy of Finland’s general research grants, Helsinky, May 2009
2010–present Coordinator of the Regional Registry of Endocrine Rare Diseases
2010-2016 President of the Adrenal Club of the Italian Endocrine Society
2011 Member of the International Organizing Committee of the 3rd Intern.
Symposium on Pheochromocytoma, Paris, France, September 2011
2011 Reviewer for the Academy of Finland’s general research grants, Helsinky, March 2011
2014 Member of the International Organizing Committee of the 4th Intern.
Symposium on Pheochromocytoma, Kyoto, Japan, Sept 2014
2014 Organization of the Congress: “Addison Disease”, Florence October 2014
2017 Member of the International Organizing Committee of the 5th Intern.
Symposium on Pheochromocytoma, Sydney, August 2017
Member of the scientific board of the Doctorate/PhD Program in
GenOMeC, University of Siena
Member of the following Scientific Societies
1) 1981 to present: Italian Society of Endocrinology
2) 1984 to 2012 Italian Society of Arterial Hypertension
3) 1990 to 1993 Medical Research Society
4) 2003 to present The Endocrine Society
5) 2003 to present European Council for Blood Pressure and Cardiovascular Research
6) 2006 to present European Network for the Study of Adrenal Tumors (ENS@T)
7) 2006 to present European Society of Endocrinology.
8) 2009 to present European NeuroEndocrine Association
First and Last Name
Resident in Endocrinology
Current research interests Prof. Mannelli has been involved, since several years, in studies on the pathophysiology of the sympathetic-adrenal system and of the adrenal cortex. He published original papers on the modulation exerted in man by prostaglandins, opioids and dopamine on catecholamine release.
In the last 20 years he focused his research on adrenal neoplasms. He published original papers on the clinics, the genetics and the diagnostic problems of pheochromocytoma. He also published original papers on the clinics and the pathogenesis of adrenocortical cancer.
He coordinated, on behalf of the Study Group on "Adrenal Tumors" of the Italian Endocrine Society a retrospective multicenter Study on Pheochromocytoma in Italy and a Study Group on the Genetics of Pheochromocytoma.
From the long lasting collaboration with the Surgical Unit of the Florence University Hospital (Azienda Ospedaliero-Universitaria di Careggi- Firenze) Prof. Mannelli is the responsible of a BioRepository containing samples of tissues, urine and blood from patients operated for adrenocortical cancer, adrenal adenomas, pheochromocytomas, abdominal, thoracic and head-and-neck paragangangliomas. The BioBank has been constituted with the approval of the Local Ethical Committee (prot. N 2009/0008394, Feb 23, 2009).
Current / recent sources of funding
1) Seventh Framework Programme (FP7/2007-2013) 2010-2015 Research program: European Network for the Study of Adrenal Tumours – Structuring clinical research on adrenal cancers in adults ENS@T Cancer 2010 grant agreement n° 259735
2) Italian Minister of University, Research and Instruction FIRB 2012-2015 Research program: Molecular markers for diagnosis/prognosis and development of novel therapeutic strategies in adrenocortical carcinoma prot number: RBAP1153LS
3) Istituto Toscano Tumori 2010-2012 Research Program: The proteomic approach for identification of putative biomarkers and characterization of the molecular bases of human adrenocortical cancer
4) Istituto Toscano Tumori 2012-2014 Research program: Succinate dehydrogenase subunit B mutations and malignant pheochromocytoma. Biochemical and functional studies in human fetal chromaffin cells and neuroblastoma cell lines
5) Fondazione Cassa di Risparmio di Pistoia e Pescia 2012-2013 Research program: Hereditary neural crest-derived tumors: Epidemiology, therapeutic options and growth mechanisms. Part 1
6) Italian Health Ministery 2012-2014 Research program: Rare adrenal tumors
7) Ente Cassa di Risparmio di Firenze 2013-2015 Research fellow: Development of primary culture of human foetal neural crest-derived cells: a model for the study of the effects of susceptibility genes mutations in pheochromocytoma
8) Fondazione Cassa di Risparmio di Pistoia e Pescia 2016-present Research program: Hereditary neural crest-derived tumors: Epidemiology, therapeutic options and growth mechanisms. Part 2
9) Paradifference Foundation 2015-present Research program: Neural crest-derived tumors and microenvironment: an experimental model to test potential therapeutical targets and drugs in SDHB-mutated paragangliomas
10 best publications of the last 5 years
1-Panizza E, Ercolino T, Mori L, Rapizzi E, Castellano M, Opocher G, Ferrero I, Neumann HPH, Mannelli M, Goffrini P. Yeast model for evaluating the pathogenic significance of SDHB, SDHC and SDHD mutations in PHEO-PGL syndrome. Hum Mol Genet 2013; 22: 804-815
2-Poli G, Guasti D, Rapizzi E, Fucci R, Bandini A, Cini N, Bani D, Mannelli M, Luconi M. Morphological and functional effects of mitotane on mitochondria in human adrenocortical cancer cells. Endocr Relat Cancer. 2013; 20(4):537-50
3-Pinzani P, Scatena C, Salvianti F, Corsini E, Canu L, Poli G, Paglierani M, Piccini V, Pazzagli M, Nesi G, Mannelli M, Luconi M. Detection of circulating tumor cells in patients with adrenocortical carcinoma: a monocentric preliminary study. J Clin Endocrinol Metab 2013; 98:3731-8
4-Assié G, Letouzé E, Fassnacht M, Jouinot A, Luscap W, Barreau O, Omeiri H, Rodriguez S, Perlemoine K, René-Corail F, Elarouci N, Sbiera S, Kroiss M, Allolio B, Waldmann J, Quinkler M, Mannelli M, Mantero F, Papathomas T, De Krijger R, Tabarin A, Kerlan V, Baudin E, Tissier F, Dousset B, Groussin L, Amar L, Clauser E, Bertagna X, Ragazzon B, Beuschlein F, Libé R, de Reyniès A, Bertherat J. Integrated genomic characterization of adrenocortical carcinoma. Nat Genet. 2014; 15:648-55
5-Castinetti F, Qi XP, Walz MK, Maia AL, Sansó G, Peczkowska M, Hasse-Lazar K, Links TP, Dvorakova S, Toledo RA, Mian C, Bugalho MJ, Wohllk N, Kollyukh O, Canu L, Loli P, Bergmann SR, Costa JB, Makay O, Patocs A, Pfeifer M, Shah NS, Cuny T, Brauckhoff M, Bausch B, von Dobschuetz E, Letizia C, Barczynski M, Alevizaki MK, Czetwertynska M, Ugurlu MU, Valk G, Plukker JT, Sartorato P, Siqueira DR, Barontini M, Szperl M, Jarzab B, Verbeek HH, Zelinka T, Vlcek P, Toledo SP, Coutinho FL, Mannelli M, Recasens M, Demarquet L, Petramala L, Yaremchuk S, Zabolotnyi D, Schiavi F, Opocher G, Racz K, Januszewicz A, Weryha G, Henry JF, Brue T, Conte-Devolx B, Eng C, Neumann HP. Outcomes of adrenal-sparing surgery or total adrenalectomy in phaeochromocytoma associated with multiple endocrine neoplasia type 2: an international retrospective population-based study. Lancet Oncol 2014; 15:648-55
6-Canu L, Rapizzi E, Zampetti B, Fucci R, Nesi G, Richter S, Qi N, Giachè V, Bergamini C, Parenti G, Valeri A, Ercolino T, Eisenhofer G, Mannelli M. Pitfalls in Genetic Analysis of Pheochromocytomas/Paragangliomas: Case Report. J Clin Endocrinol Metab 2014; 99: 2321-2326
7-Poli G, Ceni E, Armignacco R, Ercolino T, Canu L, Baroni G, Nesi G, Galli A, Mannelli M, Luconi M. 2D-DIGE proteomic analysis identifies new potential therapeutic targets for adrenocortical carcinoma. Oncotarget. 2015; 6:5695-706
8-Mannelli M, Rapizzi E, Fucci R, Canu L, Ercolino T, Luconi M, Young W. Metabolism and pheochromocytoma/paraganglioma. Endocr Relat Cancer. 2015; 22:T83-90
9-Mannelli M. Commentary. Clin Chem. 2016; 62:929. doi: 10.1373/clinchem.2015.253492.
10-Toledo RA, Burnichon N, Cascon A, Benn D, Bayley JP, Welander J, Tops C, Firth H, Dwight T, Ercolino T, Mannelli M, Opocher G, Clifton‐Bligh R , Gimm O, Maher ER, Robledo M, Gimenez‐Roqueplo AP, Dahia PLM. Consensus guidelines for next‐generation sequencing (NGS)‐based diagnostic testing of hereditary pheochromocytomas and paragangliomas. Nat Rev Endocrinol 2016
Main scientific contributions
Because of his expertise on endocrine hypertension he was invited speaker at many national and international Congresses
Prof. Mannelli published more than 50 Book Chapters, mainly on adrenal disease and about 200 papers in peer-reviewed international journals for a total impact factor value of 1096.21 Dec 2015.
Prof. Karel Pacak, National Institutes of Health (NIH), Bethesda, USA,
Dr. Zhengping Zhuang, National Institutes of Health (NIH), Bethesda, USA,
Dr. Mercedes Robledo, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid Spain,
Prof. Graeme Eisenhofer, Technische Universität Dresden, Germany,
Prof. Jens Pietzsch, Technische Universität Dresden, Germany,
Prof. Jacques Lenders, Radboud University Medical Center, Nijmegen, The Netherlands,
Prof. Peter MT Deen, Radboud University Medical Center, Nijmegen, The Netherlands,
Dr. Henri JLM Timmers, Radboud University Medical Center, Nijmegen, The Netherlands,
Prof. Natalia Pellegata, Helmholtz Institute, Munich, Germany,
Prof. Felix Beuschlein, University of Munich, Germany,
Prof. Gary Hammer, University of Mitchigan, USA,
Prof. Peter Igaz, Semmelweis University, Budapest, Hungary,
Prof. Jerome Bertherat, Paris University, France.
Other relevant information
Prof. Mannelli’s Hindex 50 (Google Scholar)