Gruppo Mannelli

Coordinator of Research Team

Name Massimo Mannelli

Position Full Professor in Endocrinology, Director of Endocrinology SOD dell’Azienda Ospedaliero-Universitaria Careggi

Name of Research Team/Laboratory Adrenal Gland Lab


telephone number 055 2758414


Brief biographical sketch of the Coordinator

Born in Florence, April 19, 1948

Degrees and Positions:

1967                     High School Degree in Florence

1973                     MD Degree at the University of Florence, Magna cum Laude

1974                      Certificate of Proficiency in English, University of Michigan, English Language Institute

1976                     Postgraduate Degree in Cardiology, University of Florence, Magna cum Laude

1979                     Postgraduate Degree in Endocrinology, University of Florence, Magna cum Laude

1974-1984                Assistant attending at the Laboratory Service, Endocrinology Unit

1984-1992                Assistant attending at the Endocrine Clinical Service, Endocrinology Unit

1992 to 2004      Associate Professor in Endocrinology, Department of Clinical

Pathophysiology, University of Florence

2004 to present Full Professor in Endocrinology, Department of Experimental and Clinical

 Biomedical Sciences, University of Florence


Teaching activities:

1982 to present:              at the Post-graduate School of Endocrinology, University of Florence.

1987-2002:                         at the post-graduate School of Nuclear Medicine, University of Florence.

1992 to present:              at the Student School of Medicine, University of Florence

1995-2001:                          Member of the Teaching Committee of the Italian Endocrine Society

2006 to present:              at the Student School of Physical Sciences, University of Florence

2010 to 2015:                    Director of the Post-graduate School of Endocrinology and Metabolism,

                                               University of Florence.


Scientific Activities:

1987                      Scientific Secretary of the International Meeting on “The Peripheral Dopaminergic System. Its role in cardiovascular homeostasis”, Florence, Italy

1992 - 1995        Member of the Scientific Committee of the Italian Endocrine Society

1998 - 1999        Coordinator of the Pheochromocytoma Study Group of the Italian Endocrine Society

2000-  2004         Associate Editor of the Journal  ²L’Endocrinologo².

2000-  2003         Member of the Board of the Italian Endocrine Society

2003-2005           Coordinator of the Scientific Committee of the Italian Endocrine Society

2003 -2012         Member of the Steering Committee of the  ENS@T (European Network for the

                               Study of the Adrenal Tumors)

2005 -2007         Coordinator of the Study Group of the Genetics of Pheochromocytoma in Italy for

                               the Italian Endocrine Society                     

2005                      Member of the International Organizing Committee of the 1st Intern. Symposium on Pheochromocytoma, NIH, Washington, October 2005

2005-present    Supervisor of the Service for the Genetic Analyses of pheochromocytoma/paraganglioma, Endocrine Laboratory, University Hospital Careggi, Florence.

2007                      Member of the International Organizing Committee of the 2nd Intern. Symposium on Pheochromocytoma, Cambridge, UK, September 2008

2007                      Organization of the 6th ENS@T Scientific Meeting, Florence, Nov. 2007

2008                      Recipient of the 39th Helen and Payne Whitney Lecturship in Medicine, “ Clinical

                               and genetic aspects of Pheochromocytoma”. North Shore Long Island Jewish

                               Medical Center, North Shore University Hospital, NY

2009                      Member of the MPGE (Malignant Pheochromocytoma Group Expert), New York,

                                May 2009

2009                    Member of the Scientific Board of the International Symposium on Adrenal

                               Tumors, Padova, September 2009

2009-present    Member of the Executive Committee of the Pheochromocytoma Research Support Organization (PRESSOR

2009                      Reviewer for the Academy of Finland’s general research grants, Helsinky, May 2009

2010–present   Coordinator of the Regional Registry of Endocrine Rare Diseases

2010-2016           President of the Adrenal Club of the Italian Endocrine Society

2011                      Member of the International Organizing Committee of the 3rd Intern.

                               Symposium on Pheochromocytoma, Paris, France, September 2011

2011                      Reviewer for the Academy of Finland’s general research grants, Helsinky, March 2011

2014                      Member of the International Organizing Committee of the 4th Intern.

                               Symposium on Pheochromocytoma, Kyoto, Japan, Sept 2014

2014                      Organization of the Congress: “Addison Disease”, Florence October 2014

2017                      Member of the International Organizing Committee of the 5th Intern.

                               Symposium on Pheochromocytoma, Sydney, August 2017



Member of the scientific board of the Doctorate/PhD Program in

GenOMeC, University of Siena


Member of the following Scientific Societies

1) 1981 to present:         Italian Society of Endocrinology

2) 1984 to 2012                 Italian Society of Arterial Hypertension

3) 1990 to 1993                 Medical Research Society

4) 2003 to present          The Endocrine Society

5) 2003 to present          European Council for Blood Pressure and Cardiovascular Research

6) 2006 to present          European Network for the Study of Adrenal Tumors (ENS@T)

7) 2006 to present          European Society of Endocrinology.

8) 2009 to present          European NeuroEndocrine Association  


Research Team


First and Last Name


Massimo Mannelli

Full Professor

Michaela Luconi

Associate Professor

Elena Rapizzi

Research fellow

Serena Martinelli

Research fellow

Vanessa D’Antongiovanni

Research fellow

Letizia Canu

Resident in Endocrinology

Giada Poli

Research fellow

Roberta Armignacco

PhD student

Gabriele Parenti

Medical Doctor

Tonino Ercolino

Genetic specialist

Valentino Giaché



Current research interests  Prof. Mannelli has been involved, since several years, in studies on the pathophysiology of the sympathetic-adrenal system and of the adrenal cortex. He published original papers on the modulation exerted in man by prostaglandins, opioids and dopamine on catecholamine release.

In the last 20 years he focused his research on adrenal neoplasms. He published original papers on the clinics, the genetics and the diagnostic problems of pheochromocytoma. He also published original papers on the clinics and the pathogenesis of adrenocortical cancer.

He coordinated, on behalf of the Study Group on "Adrenal Tumors" of the Italian Endocrine Society a retrospective multicenter Study on Pheochromocytoma in Italy and a Study Group on the Genetics of Pheochromocytoma.

From the long lasting collaboration with the Surgical Unit of the Florence University Hospital (Azienda Ospedaliero-Universitaria di Careggi- Firenze) Prof. Mannelli is the responsible of a BioRepository containing samples of tissues, urine and blood from patients operated for adrenocortical cancer, adrenal adenomas, pheochromocytomas, abdominal, thoracic and head-and-neck paragangangliomas. The BioBank has been constituted with the approval of the Local Ethical Committee (prot. N 2009/0008394, Feb 23, 2009).


Current / recent sources of funding

1) Seventh Framework Programme (FP7/2007-2013) 2010-2015 Research program: European Network for the Study of Adrenal Tumours – Structuring clinical research on adrenal cancers in adults ENS@T Cancer 2010 grant agreement n° 259735

2) Italian Minister of University, Research and Instruction FIRB 2012-2015 Research program: Molecular markers for diagnosis/prognosis and development of novel therapeutic strategies in adrenocortical carcinoma prot number: RBAP1153LS

3) Istituto Toscano Tumori  2010-2012   Research Program: The proteomic approach for identification of putative biomarkers and characterization of the molecular bases  of human adrenocortical cancer

4) Istituto Toscano Tumori  2012-2014   Research program: Succinate dehydrogenase subunit B mutations and malignant pheochromocytoma. Biochemical and functional studies in human fetal chromaffin cells and neuroblastoma cell lines 

5) Fondazione Cassa di Risparmio di Pistoia e Pescia 2012-2013 Research program: Hereditary neural crest-derived tumors: Epidemiology, therapeutic options and growth mechanisms. Part 1

6) Italian Health Ministery 2012-2014    Research program: Rare adrenal tumors 

7) Ente Cassa di Risparmio di Firenze    2013-2015 Research fellow: Development of primary culture of human foetal neural crest-derived cells: a model for the study of the effects of susceptibility genes mutations in pheochromocytoma

8) Fondazione Cassa di Risparmio di Pistoia e Pescia 2016-present Research program: Hereditary neural crest-derived tumors: Epidemiology, therapeutic options and growth mechanisms. Part 2

9) Paradifference Foundation 2015-present Research program: Neural crest-derived tumors and microenvironment: an experimental model to test potential therapeutical targets and drugs in SDHB-mutated paragangliomas


10 best publications of the last 5 years

1-Panizza E, Ercolino T, Mori L, Rapizzi E, Castellano M, Opocher G, Ferrero I, Neumann HPH, Mannelli M, Goffrini P. Yeast model for evaluating the pathogenic significance of SDHB, SDHC and SDHD mutations in PHEO-PGL syndrome. Hum Mol Genet 2013; 22: 804-815

2-Poli G, Guasti D, Rapizzi E, Fucci R, Bandini A, Cini N, Bani D, Mannelli M, Luconi M.  Morphological and functional effects of mitotane on mitochondria in human adrenocortical cancer cells. Endocr Relat Cancer. 2013; 20(4):537-50

3-Pinzani P, Scatena C, Salvianti F, Corsini E, Canu L, Poli G, Paglierani M, Piccini V, Pazzagli M, Nesi G, Mannelli M, Luconi M.  Detection of circulating tumor cells in patients with adrenocortical carcinoma: a monocentric preliminary study. J Clin Endocrinol Metab 2013;  98:3731-8

4-Assié G, Letouzé E, Fassnacht M, Jouinot A, Luscap W, Barreau O, Omeiri H, Rodriguez S, Perlemoine K, René-Corail F, Elarouci N, Sbiera S, Kroiss M, Allolio B, Waldmann J, Quinkler M, Mannelli M, Mantero F, Papathomas T, De Krijger R, Tabarin A, Kerlan V, Baudin E, Tissier F, Dousset B, Groussin L, Amar L, Clauser E, Bertagna X, Ragazzon B, Beuschlein F, Libé R, de Reyniès A, Bertherat J. Integrated genomic characterization of adrenocortical carcinoma. Nat Genet. 2014;      15:648-55

5-Castinetti F, Qi XP, Walz MK, Maia AL, Sansó G, Peczkowska M, Hasse-Lazar K, Links TP, Dvorakova S, Toledo RA, Mian C, Bugalho MJ, Wohllk N, Kollyukh O, Canu L, Loli P, Bergmann SR, Costa JB, Makay O, Patocs A, Pfeifer M, Shah NS, Cuny T, Brauckhoff M, Bausch B, von Dobschuetz E, Letizia C, Barczynski M, Alevizaki MK, Czetwertynska M, Ugurlu MU, Valk G, Plukker JT, Sartorato P, Siqueira DR, Barontini M, Szperl M, Jarzab B, Verbeek HH, Zelinka T, Vlcek P, Toledo SP, Coutinho FL, Mannelli M, Recasens M, Demarquet L, Petramala L, Yaremchuk S, Zabolotnyi D, Schiavi F, Opocher G, Racz K, Januszewicz A, Weryha G, Henry JF, Brue T, Conte-Devolx B, Eng C, Neumann HP. Outcomes of adrenal-sparing surgery or total adrenalectomy in phaeochromocytoma associated with multiple endocrine neoplasia type 2: an international retrospective population-based study. Lancet Oncol 2014; 15:648-55

6-Canu L, Rapizzi E, Zampetti B, Fucci R, Nesi G, Richter S, Qi N, Giachè V, Bergamini C, Parenti G, Valeri A, Ercolino T, Eisenhofer G, Mannelli M. Pitfalls in Genetic Analysis of Pheochromocytomas/Paragangliomas: Case Report. J Clin Endocrinol Metab 2014; 99: 2321-2326

7-Poli G, Ceni E, Armignacco R, Ercolino T, Canu L, Baroni G, Nesi G, Galli A, Mannelli M, Luconi M. 2D-DIGE proteomic analysis identifies new potential therapeutic targets for adrenocortical carcinoma. Oncotarget. 2015; 6:5695-706


8-Mannelli M, Rapizzi E, Fucci R, Canu L, Ercolino T, Luconi M, Young W. Metabolism and pheochromocytoma/paraganglioma. Endocr Relat Cancer. 2015; 22:T83-90


9-Mannelli M. Commentary. Clin Chem.  2016; 62:929. doi: 10.1373/clinchem.2015.253492.


10-Toledo RA, Burnichon N, Cascon A, Benn D, Bayley JP, Welander J, Tops C, Firth H, Dwight T, Ercolino T, Mannelli M, Opocher G, Clifton‐Bligh R , Gimm O, Maher ER, Robledo M, Gimenez‐Roqueplo AP, Dahia PLM. Consensus guidelines for next‐generation sequencing (NGS)‐based diagnostic testing of hereditary pheochromocytomas and paragangliomas. Nat Rev Endocrinol 2016

Main scientific contributions

Because of his expertise on endocrine hypertension he was invited speaker at many national and international Congresses

Prof. Mannelli published more than 50 Book Chapters, mainly on adrenal disease and about 200 papers in peer-reviewed international journals for a total impact factor value of 1096.21 Dec 2015.



Prof. Karel Pacak, National Institutes of Health (NIH), Bethesda, USA,

Dr. Zhengping Zhuang, National Institutes of Health (NIH), Bethesda, USA,

Dr. Mercedes Robledo, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid Spain,

Prof. Graeme Eisenhofer, Technische Universität Dresden, Germany,

Prof. Jens Pietzsch, Technische Universität Dresden, Germany,

Prof. Jacques Lenders, Radboud University Medical Center, Nijmegen, The Netherlands,

Prof. Peter MT Deen, Radboud University Medical Center, Nijmegen, The Netherlands,

Dr. Henri JLM Timmers, Radboud University Medical Center, Nijmegen, The Netherlands,

Prof. Natalia Pellegata, Helmholtz Institute, Munich, Germany,

Prof. Felix Beuschlein,  University of Munich, Germany,

Prof. Gary Hammer, University of Mitchigan, USA,

Prof. Peter Igaz, Semmelweis University, Budapest, Hungary,

Prof. Jerome Bertherat, Paris University, France.


Other relevant information

Prof. Mannelli’s Hindex 50 (Google Scholar)

Ultimo aggiornamento



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