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SBSC Dipartimento di Scienze Biomediche Sperimentali e Cliniche

Gruppo Rotella

Coordinator of Research Team


Full Professor


telephone number…055-2758104



Brief biographical sketch of the Coordinator

Born in Florence, 5-11-1948

1974 M.D. University of Florence, Florence, Italy

1978 Clinical Endocrinology SpecialiST, University of Florence, Florence, Italy


Member of the scientific board of the Doctorate/PhD Program in………………………………………………..

Coordinator of the Section on Endocrinological, Molecular and Rigenerative Biothecnologies of the PhD Biomedical Sciences

Member of the following Scientific Societies

- Society of Italian Endocrinology

- Society of Italian Diabetology

- Association of Physicians in Diabetology (AMD)

- Italian Society for the Study of Obesity (until 2000)

- Italian Society of Obesity (since 2000)

1992-97 Member of the governing Board of the Italian Society Endocrinology

1995-97 Secretary of the Company Italian Endocrinology

1998-00 Member of the governing Board of the Italian Society for the Study of Obesity

1999-01 President of the Tuscany Section of the Italian Society of Diabetology

1998-02 Coordinator of the Study Group of Ocular Complications of the Italian Society of Diabetology

2002-06 Member of the governing  Board of the Italian Society of Diabetology and person in charge for the Educational Committee

2004-06 Member of the governing  Board  of the Italian Society Obesity and President Elect

2006-08 President of the Italian Society of Obesity

2008-10 Past President of the Italian Society of Obesity

2014 up to now, President of the Tuscany Section of the Italian Society of Obesity


Member of the editorial board of the following Journals

1) Eating an weight disorders and Obesity

2) Addictive Behaviors

                3)  Acta Endocrinologica



Research Team

1) Edoardo Mannucci, 11th June 1965: Medical Doctor (1990), Post-graduate degree of Endocrinology and Metabolic Diseases (1995)

2) Astrid Parenti, 27th  December 1964: Biological Science (1990), Post-graduate degree of Pharmacology (1993), PhD in Pharmacology and Toxicology (1998)

3) Michaela Luconi, 28th June 1968: Biological Sciences (1993), PhD in Endocrinlogy (1999)


Current research interests  

Prof. Rotella is the project Manager of "Therapy of the obese patients”

Pathophysiology of obesity

Metabolic syndrome and Vascular remodeling

pathophysiology  of GLP1 agonists and DPP IV inhibitors

hypertriglyceridemia and diabetic nephropathy


Current / recent sources of funding

Private fundings


10 best publications of the last 5 years


Association between plasma triglycerides and high-density lipoprotein cholesterol and microvascular kidney disease and retinopathy in type 2 diabetes mellitus: a global case-control study in 13 countries.

Sacks FM, Hermans MP, Fioretto P, Valensi P, Davis T, Horton E, Wanner C, Al-Rubeaan K, Aronson R, Barzon I, Bishop L, Bonora E, Bunnag P, Chuang LM, Deerochanawong C, Goldenberg R, Harshfield B, Hernández C, Herzlinger-Botein S, Itoh H, Jia W, Jiang YD, Kadowaki T, Laranjo N, Leiter L, Miwa T, Odawara M, Ohashi K, Ohno A, Pan C, Pan J, Pedro-Botet J, Reiner Z, Rotella CM, Simo R, Tanaka M, Tedeschi-Reiner E, Twum-Barima D, Zoppini G, Carey VJ.

Circulation. 2014 Mar 4;129(9):999-1008.



The use of statins in people at risk of developing diabetes mellitus: evidence and guidance for clinical practice.

Sattar NA, Ginsberg H, Ray K, Chapman MJ, Arca M, Averna M, Betteridge DJ, Bhatnagar D, Bilianou E, Carmena R, Ceška R, Corsini A, Erbel R, Flynn PD, Garcia-Moll X, Gumprecht J, Ishibashi S, Jambart S, Kastelein JJ, Maher V, da Silva PM, Masana L, Odawara M, Pedersen TR, Rotella CM, Salti I, Teramoto T, Tokgozoglu L, Toth PP, Valensi P, Vergès B.

Atheroscler Suppl. 2014 Jun;15(1):1-15. doi: 10.1016/j.atherosclerosissup.2014.04.001. Review.



Effects of glucagon-like peptide-1 receptor agonists on body weight: a meta-analysis.

Monami M, Dicembrini I, Marchionni N, Rotella CM, Mannucci E.

Exp Diabetes Res. 2012;2012:672658. doi: 10.1155/2012/672658.



Dyslipidemia and diabetes: reciprocal impact of impaired lipid metabolism and Beta-cell dysfunction on micro- and macrovascular complications.

Bardini G, Rotella CM, Giannini S.

Rev Diabet Stud. 2012 Summer-Fall;9(2-3):82-93. doi: 10.1900/RDS.2012.9.82. Review.



Further data on beta-blockers and cancer risk: observational study and meta-analysis of randomized clinical trials.

Monami M, Filippi L, Ungar A, Sgrilli F, Antenore A, Dicembrini I, Bagnoli P, Marchionni N, Rotella CM, Mannucci E.

Curr Med Res Opin. 2013 Apr;29(4):369-78. doi: 10.1185/03007995.2013.772505.



Different modulation of dipeptidyl peptidase-4 activity between microvascular and macrovascular human endothelial cells.

Pala L, Pezzatini A, Dicembrini I, Ciani S, Gelmini S, Vannelli BG, Cresci B, Mannucci E, Rotella CM.

Acta Diabetol. 2012 Dec;49 Suppl 1:S59-63. doi: 10.1007/s00592-010-0195-3.



The role of DPP4 activity in cardiovascular districts: in vivo and in vitro evidence.

Pala L, Rotella CM.

J Diabetes Res. 2013;2013:590456. doi: 10.1155/2013/590456. Review.



Bone: incretin hormones perceiver or receiver?

Dicembrini I, Mannucci E, Rotella CM.

Exp Diabetes Res. 2012;2012:519784. doi: 10.1155/2012/519784. Review.



Cardiovascular health in migrants: current status and issues for prevention. A collaborative multidisciplinary task force report.

Modesti PA, Bianchi S, Borghi C, Cameli M, Capasso G, Ceriello A, Ciccone MM, Germanò G, Maiello M, Muiesan ML, Novo S, Padeletti L, Palmiero P, Pillon S, Rotella CM, Saba PS, Scicchitano P, Trimarco B, Volpe M, Pedrinelli R, Di Biase M; Societa' Italiana di Cardiologia (SIC).; Societa' Italiana dell'Ipertensione Arteriosa (SIIA).; Societa' Italiana di Medicina Interna (SIMI).; Societa' Italiana di Nefrologia (SIN).; Associazione Medici Diabetologi (AMD).; Associazione Italiana Aritmia e Cardiostimolazione (AIAC).; Società Italiana dell'Obesità (SIO).; Societa' Italiana di Prevenzione Cardiovascolare (SIPREC).; Osservatorio Nazionale della Sanità Elettronica e Telemedicina (ONSET)..

J Cardiovasc Med (Hagerstown). 2014 Sep;15(9):683-92. doi: 10.2459/JCM.0000000000000069.



Sustained exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes.

Di Pasquale G, Dicembrini I, Raimondi L, Pagano C, Egan JM, Cozzi A, Cinci L, Loreto A, Manni ME, Berretti S, Morelli A, Zheng C, Michael DG, Maggi M, Vettor R, Chiorini JA, Mannucci E, Rotella CM.

PLoS One. 2012;7(7):e40074. doi: 10.1371/journal.pone.0040074.


Previous research experiences

-after 1990, topic was on metabolic research: pathophysiology of diabetes mellitus and its complications

-after 1995, topic was on clinical and pathophysiology of obesity and eating disorders, hyperlipoproteinemias

ultimo aggiornamento: 26-Set-2017
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