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SBSC Dipartimento di Scienze Biomediche Sperimentali e Cliniche

gruppo Brandi

 

GRUPPO BRANDI

 

 Coordinator of Research Team

Name: Maria Luisa Brandi

Position: Full Professor MED13

Name of Research Team/Laboratory: Cellular and Molecular Biology and Genetic Lab

e-mail: marialuisa.brandi@unifi.it

telephone number: +390557946303

 

 

Brief biographical sketch of the Coordinator

Date of birth: 31st July 1953, Viterbo (Italy).

Year

Degree and Field of study

Institution

City

Country

1977

Degree in Medicine

University of Florence

Florence

Italy

1980

Postgraduate School in Endocrinology

University of Florence

Florence

Italy

1988

PhD in Cell Biology

University of Rome

Rome

Italy

1980-1984

Research Associate in Medicine

University of Florence

Florence

Florence

1984-1985

Fellow of the italian association for cancer research

NIH

Bethesda

United States of America

1985-1986

Visiting Fellow

NIH

Bethesda

United States of America

1986-1988

Visiting Associate

NIH

Bethesda

United States of America

1988-1992

Assistant Professor of metabolic disease

University of Florence

Florence

Italy

1992-2003

Associate Professor of metabolic disease

University of Florence

Florence

Italy

1993-1994

Visiting Scientist

The William Harvey Research Institute

London

United Kingdom

1996

UICC Fellow

NIDDK,NIH

Bethesda

United States of America

1998

UICC Fellow

NIDDK,NIH

Bethesda

United States of America

2001

UICC Fellow

Mount Sinai Medical Center

New York

United States of America

1998

Director of the Regional Center for Hereditary Endocrine Tumours

A.O.U.C Azienda Ospedaliero-Universitaria Careggi-Firenze

Florence

Italy

2003

Full Professor of Endocrinology and Metabolic Diseases

University of Florence

Florence

Italy

2007

Director of the Unit “Malattie del metabolism minerale e osseo”

A.O.U.C Azienda Ospedaliero-Universitaria Careggi-Firenze

Florence

Italy

 

Member of the scientific board of the Doctorate/PhD Program in:

Clinical Sciences_Curriculum: Pathology and Clinic of the Locomotor System and Calcified Tissue, University of Florence.

Member of the following Scientific Societies

ASBMR; American Association of Clinical Endocrinologists; Endocrine Society;

International Bone and Mineral Society;

Italian Society of Endocrinology;

Italian Society of Internal Medicine;

Scientific Committee, International Osteoporosis Foundation;

Scientific Committee Member of Osservatorio Nazionale sulla salute della Donna (O.N.Da);

General Secretary of European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO);

Executive Director OrtoMed Society;

Member Board International Osteoporosis Foundation (IOF);

In the past she was: President, S.I.O.M.M.M.S. (Italian Society of Osteoporosis and Metabolic Bone Diseases), 2005-2007;

Member of no profit research Foundations

President and Founds Raiser for Fondazione Italiana Ricerca sulle Malattie dell’Osso (F.I.R.M.O. Foundation ONLUS), 2006 – to presen

Member of the Editorial Board of the following Journals

Journal of Endocrinological Investigation, 1990-1994;

Diabetes, Nutrition and Metabolism, 1990-1998;

Calcified Tissue International, 2013-to present;

Expert Opinion on Investigational Drugs, 2002–to present;

Endocrinology, 2004-2007;

2000 Medicine, 2004-to present.

Journal of Bone and Mineral Research, 2008-2012;

World Journal of Clinical Cases, 2016-to present;

Editor-in-Chief of Clinical Cases in Bone and Mineral Metabolism, 2004–to present;

Orphanet Journal of Rare Diseases (Section: Rare endocrinological diseases)

Research Team

  1. Anna Maria Carossino (RC)
  2. Roberto Carossino (C)
  3. Luisella Cianferotti, MD, PhD, (RTD)
  4. Simone Ciuffi, Research Fellow
  5. Lisa Di Medio, MD, PhD Student
  6. Vladana Domazetovic, PhD, Post Doc
  7. Sergio Fabbri, PhD, Post Doc
  8. Caterina Fossi, PhD, Post Doc
  9. Francesco Franceschelli (EP)
  10. Gianna Galli (EP)
  11. Leonardo Guasti, PhD Student
  12. Francesca Giusti, MD
  13. Gigliola Leoncini PhD,(EP)
  14. Gemma Marcucci, MD, PhD, (RTD)
  15. Gaia Palmini, PhD, Post Doc
  16. Barbara Pampaloni, PhD, Post Doc
  17. Sara Quattrini, PhD Student
  18. Cecilia Romagnoli, PhD, Post Doc
  19. Giorgia Zappoli (C)
  20. Roberto Zonefrati (EP)

 

Current research interest

  • Genetics and Clinics of Osteoporosis;
  • Pathogenesis of Parathyroid Disorders;
  • Multiple Endocrine Neoplasia;
  • Genetics of Paget’s Disease of Bone;
  • Bone Cell Biology;
  • Epidemiology of Osteoporosis;
  • Bone Inherited Disorders.
  • Epidemiology and Prevention of Fragility Fractures, Development of Original Models to solve the Set of Problems related to Fragility Fractures, Evaluation of Pharmacoeconomic Factors related to Fragility Fractures.

Current/recent source of founding

Recent sources: University of Florence (Fondi di Ateneo), Italian Ministry of University and Research (MIUR), Italian Ministry of Health, Ente Cassa di Risparmio Foundation (Florence), Marie Skłodowska-Curie Innovative Training Network (ITN-ETN) H2020-MSCA-ITN-2015, FESR-Por CREO (2007-2013), Tuscany Region, Istituto Toscano Tumori (ITT).

 

10 best publications of 2017-2018

  1. The authors reply: Letter on: "Pitfalls in the measurement of muscle mass: a need for a reference standard" by Clark et al. Buckinx F, Landi F, Cesari M et al. J Cachexia Sarcopenia Muscle. 2018.
  2. The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases. Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV. Nat Rev Endocrinol. 2018.
  3. Does nutrition play a role in the prevention and management of sarcopenia? Robinson SM, Reginster JY, Rizzoli R et al. Clin Nutr. 2018.
  4. The Authors reply: "Dual energy X-ray absorptiometry: gold standard for muscle mass?" by Scafoglieri et al. Buckinx F, Landi F, Cesari M et al. J Cachexia Sarcopenia Muscle. 2018.
  5. Pitfalls in the measurement of muscle mass: a need for a reference standard. Buckinx F, Landi F, Cesari M et al. J Cachexia Sarcopenia Muscle. 2018.
  6. Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density. Alonso N, Estrada K, Albagha OME et al. Ann Rheum Dis. 2018.
  7. Impairment of PTX3 expression in osteoblasts: a key element for osteoporosis. Scimeca M, Salustri A, Bonanno E et al. Cell Death Dis. 2017.
  8. Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis. Saag KG, Petersen J, Brandi ML et al. N Engl J Med. 2017.
  9. Hip Arthropathy in Haemophilia. Carulli C, Rizzo AR, Innocenti M. J Clin Med. 2017.
  10. 10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension. Bone HG, Wagman RB, Brandi ML, Brown JP et al. Lancet Diabetes Endocrinol. 2017.

 

Main Scientific Contributions

The research group headed by Prof. Maria Luisa Brandi contributes during the last years is focused on

  • study of the clinical, epidemiological, genetic and epigenetic aspects of several bone mineral metabolism diseases (i.e osteoporosis, Hypophosphatasia, Parathyroid cancer, Pathogenesis of Parathyroid Disorders; Multiple Endocrine Neoplasia (MEN1, MEN2, MEN4, FHH, FPHT, HPT-JT e VHL));
  • Study of the skeletal muscle tissue as an endocrine tissue. Estasblishment and characterization of in vitro cellular models of myogenic differentiation to find new therapies for musculoskeletal diseases (i.e sarcopenia);
  • Study the musculoskeletal disorders with the final aim to find new therapies for the treatment of musculoskeletal pain;
  • Study of the cellular and molecular processes at the base of the osteogenic differentiation of in vitro mesenchymal stem cell models in relation to the mineral bone metabolism disorders;
  • Study of the biology, genetic and epigenetic of primary bone tumors;
  • Study on miRNAs on mineral and bone metabolism disorders;

 

Prof. Maria Luisa Brandi is the authior of over 700 papers in peerly reviewed journals and 250 chapters and books.

Main Collaborations

Prof. Rajesh Thakker (Oxford, United Kingdom);

Stephen J. Marx (NIH, Bethesda, United States of America)

Prof. JA Eisman (University of Sydney, Australia)

Prof. Jean-Yves Reginster (University of Liège, Belgium)

 
ultimo aggiornamento: 12-Nov-2019
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