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SBSC Dipartimento di Scienze Biomediche Sperimentali e Cliniche

Gruppo Luconi

Coordinator of Research Team

Name MICHAELA LUCONI

Position ASSOCIATE PROFESSOR

Name of Research Team/Laboratory biology of the adipose organ

e-mail michaela.luconi@unifi.it

telephone number +39 055 2758239

 

 

 

 

              

Brief biographical sketch of the Coordinator

Born in Florence, 28 June 1968

1999                      PhD in Endocrinology and Metabolism Dept. Clinical Pathophysiology/University of Florence/Italy        

1995                      MSc Degree in Biology (summa cum laude)  (Biochemistry)/University of Florence/Italy

Orcid number   0000-0001-5186-064X

Reasearch ID     K-6693-2016

Member of the scientific board of the Doctorate/PhD Program

2015-                     School of Medicine of Erasmus Placement Program, University of Florence/Italy

2014                      Member of the Erasmus Placement Program Panel: Department of Clinical Pathobiochemistry, University of Dresden/Germany PhD/MD Program in Molecular Endocrinology

2012-                    Scientific Committee of the Excellence Center DENOTHE/University of Florence/Italy

2005-                    Member of the Collegium for PhD in Endocrine, Molecular and Regenerative Biotechnologies/University of Florence/Italy

 

Member of the following Scientific Societies

2016-                    Italian Society of Diabetology (SID)

2013-                    European Association for the Study of Diabetes (EASD)

2009-                    European Society of Endocrinology (ESE)

2008-                    European Network for the Study on Adrenal Tumors (ENSAT)

2000-                     Italian Society of Endocrinology (SIE)

 

Member of the editorial board of the following Journals

2013-                     Associate Editor Frontiers in Cancer Endocrinology

2009-                     Editorial Board Inflammation & Allergy - Drug Targets

2005-2008           Editorial Board SIAMs

 

 

Research Team

1) Gianni Forti, 24 December 1945: MD (1973), Full Professor in Endocrinology (1990)

2) Giulia Cantini, 17 November 1981: MSc Biological Science (2006), PhD in Endocrinological, Molecular and Regenerative Biotechnologies (2012)

3) Alessandra Di Franco, 17 November 1984: MSc Medical Biotechnologies (2010), PhD in Endocrinological, Molecular and Regenerative Biotechnologies (2016)

4) Giada Poli, 20 December 1978: MSc Biological Sciences (2005), PhD in Endocrinological, Molecular and Regenerative Biotechnologies (2015)

5) Roberta Armignacco, 28 February 1988: MSc Medical Biotechnologies (2012), PhD Student in Endocrinological, Molecular and Regenerative Biotechnologies

 

Current research interests 

BIOLOGY OF THE ADIPOSE TISSUE

BIOLOGY OF VASCULAR ENDOTHELIUM

MOLECULAR MECHANISMS OF DEVELOPMENT AND PROGRESSION OF ADRENAL CARCINOMA

 

Current / recent sources of funding

Principal Investigator:

  • 2016-2018 PRIN: PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE – Bando 2015 “Defective tissue repair in metabolic disorders: untangling its role and key mechanisms for novel therapeutic approaches“;  Coordinator Prof. Andrea Isidori
  • 2016 AIRC-CRF Multi-user Equipment Program “Assaying tumor metabolic deregulation in live cells” Coordinator Prof. P. Chiarugi
  • 2016 Università di Firenze: ex 60% “Metabolic Reprogramming in Adrenocortical Carcinoma (ACC): searching master regulators as potential targets for innovative therapies”. 
  • 2016-2018 AIRC Investigator Grant AIRC 2014 3 year granted project: "DIFFERENTIAL GENOME PROFILING BETWEEN CIRCULATING AND PRIMARY TUMOR CELLS IN METASTATIC ADRENOCORTICAL CARCINOMA
  • 2016 University of Florence: “Stem cell fate decisions in a tumor microenvironment: A potential role for p107”
  • 2015 Università di Firenze: ex 60% “THE ROLE OF BONE MORPHOGENIC PROTEIN 7 (BMP7) IN TUMOR CROSS-TALK WITH ADIPOSE MICROENVIRONMENT IN PHEOCHROMOCYTOMA”

 

Collaborator:

  • 2016-2018 Liberal Fund non profit PARADIFFERENCE. “The roles of microenvironment and mitochondria succinate dehydrogenase in paraganglioma development and progression". In Prof. Mannelli’s Unit.
  • 2014-2015  Fondazione Ente Cassa di Risparmio di Firenze 2014. EFFETTO DELL’OBESITA’ E DELLA PERDITA DI PESO SULLO STATO DI METILAZIONE DEL GAMETE MASCHILE: EFFETTI METABOLICI E EREDITARIETA’ PATERNA. Prof. G.Forti
  • 2011-2015 PRIN 2010-2011 “AMLET - ANDROGENI, METABOLISMO, STILE DI VITA, AMBIENTE: FUNZIONE TESTICOLARE PER LA SALUTE”-protocollo 2010C8ERKX in Prof. G. Forti’s Unit 7, Coordinator Prof.ssa Manuela Simoni (Università degli Studi di Modena).
  • 2011-2015 FP7 Cooperation “ENS@T-Cancer-EUROPEAN NETWORK FOR THE STUDY OF ADRENAL TUMOURS –STRUCTURING CLINICAL RESEARCH ON ADRENAL CANCERS IN ADULTS” Progetto Cooperation Seventh Framework Programme (FP7/2007-2013) grant agreement n° 259735, in Prof. Massimo Mannelli’s Unit, Coordinatore Prof. Felix Beuschlein (University of Munich, GE).
  • 2011-2015 FIRB2010 “STUDY OF MOLECULAR MARKERS FOR DIAGNOSIS AND PROGNOSIS AND DEVELOPMENT OF NOVEL THERAPEUTIC STRATEGIES FOR ADRENOCORTICAL CANCER” (prot number: RBAP1153LS) in Prof. Massimo Mannelli’s Unit, Coordinator Prof. Franco Mantero (Università degli Studi di Padova)

 

10 best publications of the last 5 years

Correspondent Author; IF 2015-2016

 

[1]    Luconi M, Samavat J, Seghieri G, Iannuzzi G, Lucchese M, Rotella C, Forti G, Maggi M, Mannucci E. Determinants of testosterone recovery after bariatric surgery: Is it only a matter of reduction of body mass index?  Fertil Steril. 2013;99:1872-1879.e1. IF: 4.426;

[2]    Samavat J, Facchiano E, Cantini G, Di Franco A, Alpigiano G, Poli G, Seghieri G, Lucchese M, Forti G, Luconi M*. Osteocalcin increase after bariatric surgery predicts androgen recovery in hypogonadal obese males. Int J Obesity (Lond). 2014;38:357-63. IF:5.337

[3]    Di Franco A, Guasti D, Mazzanti B, Ercolino T, Francalanci M, Nesi G, Bani D, Forti G, Mannelli M, Valeri A, Luconi M*. Dissecting the origin of inducible brown fat in adult humans through a novel adipose stem cell model from adipose tissue surrounding pheochromocytoma.  J Clin Endocrinol Metab. 2014;99:E1903-12. IF: 5.531

[4]    Samavat J, Facchiano E, Lucchese M, Forti G, Mannucci E, Maggi M, Luconi M*. Hypogonadism as an additional indication for bariatric surgery in male morbid obesity? Eur J Endocrinol. 2014;171:555-60. IF: 3.892

[5]    Samavat J, Natali I, Degl'Innocenti S, Filimberti E, Cantini G, Di Franco A, Danza G, Seghieri G, Lucchese M, Baldi E, Forti G, Luconi M*. Acrosome reaction is impaired in spermatozoa of obese men: a preliminary study. Fertil Steril. 2014 102:1274-1281. IF: 4.426

[6]    Cantini G, Di Franco A, Samava J, Forti G, Mannucci E, Luconi M*. Effect of liraglutide on proliferation and differentiation of human adipose stem cells. Mol Cel Endocrinol 2015;402:43-50. IF:3.859

[7]    Di Franco A, Guasti D, Squecco R, Mazzanti B, Rossi F, Idrizaj E, Gallego-Escuredo JM, Villarroya F, Bani D, Forti G, Vannelli GB, Luconi M*. Searching for classical brown fat in humans: development of a novel human fetal brown stem cell model. Stem Cells 2016;34:1679-91. IF: 5.902;

[8]    Cantini G, Mannucci E, Luconi M*. Perspectives in GLP-1 Research: New Targets, New Receptors. Trends Endocrinol Metab. 2016;27:427-38. IF:8.964

[9]    Luconi M*, Cantini G, Ceriello A, Mannucci E. Perspectives on cardiovascular effects of incretin-based drugs: From bedside to bench, return trip. Int J Cardiol. 2017;241:302-310. IF: 4.638

[10]Samavat J, Cantini G, Lotti F, Di Franco A, Tamburrino L, Degl’Innocenti S, Maseroli E, Filimberti E, Facchiano E, Lucchese M,  Muratori M, Forti G, Baldi E, Maggi M, Luconi M*. Massive Weight Loss Obtained by Bariatric Surgery Affects Semen Quality in Morbid Male Obesity: a Preliminary Prospective Double-Armed Study. Obesity Surgery, 2017 in press. IF: 3.947

 

Previous research experiences

1994-2004          reproductive biology

spermatology

biology of the steroid hormones

 

Main scientific contributions

BIOLOGY OF THE ADIPOSE TISSUE

BIOLOGY OF VASCULAR ENDOTHELIUM

MOLECULAR MECHANISMS OF DEVELOPMENT AND PROGRESSION OF ADRENAL CARCINOMA

 

Collaborations

Dr. Enzo Lalli, CNRS-University Sophia Antipolis, Valbonne, Nice, France: “Vav2 in adrenal tumors”

Prof. F. Villarroya, University of Barcellona, Spain: “FGF21 in the browning process”

Prof. A. Scime, University of York, Toronto, Canada: “Adipose microenvironment in adrenal tumors”Prof.

Prof. N. Pellegata, Helmholtz Institute, Munich, Germany: “BMP7 and brown adipogenesis”

Prof. T. Chavakis, Technishe Universitat Dresden, Germany: “Immunological bases of obesity”

Prof. F. Beuschlein,  University of Munich, Germany & ENSAT: “Molecular bases of adrenal cancer”

Prof. G. Hammer, University of Mitchigan, USA: “Molecular bases of human fetal adrenal development”

Prof. P. Igaz, Semmelweis University, Budapest, Hungary: “microRNA and adrenocortical cancer”

Prof. J. Bertherat, Paris University, France: “Genomics of adrenocortical cancer”

 

Other relevant information

  • 2014-                         Evaluator Marie Sklodowska-Curie Horizon2020: Life Science panel REA
  • 2010- 2014              Evaluator for Marie Curie Marie Curie FP7:  Life Science panel REA

 

  • Reviewer of international and national Research Grants in Netherlands, France, Hungary, Italy.
  • Reviewer for international journals in the field of Stem Cells, Metabolism, Endocrinology and Reproduction, such as Diabetes, Diabetologia, Endocrinol, Endocr-Rel Cancer, FASEB J, Horm & Cancer, J Endocrinol, J Cardiovasc Pharmacol, J Clin Endocrinol Metab, J Nephrol, J Urology, Mol Cel Endocrinol,Oncotarget, PLOS One, Stem Cells.

 

  • TEACHING ACTIVITIES

2015-                     Master in Radiotherapy University of Florence/Italy

2013-                     Medical Specialization in Endocrinology University of Florence/Italy

2005-                     MSc in Medical & Pharmaceutical Biotechnology, University of Florence/Italy

2005-                     PhD Program in Endocrine, Molecular & Regenerative Biotechnologies University of Florence/Italy

  • SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS

6 PhD Students/University of Florence/Italy

                                2 resident specialization students Endocrinology & Metabolic Pathologies/University of Florence/Italy

5 Post-doc Students/University of Florence/Italy

1 BSc ERASMUS student /University of Barcelona/Spain

28 MD, MSc, BSc students (Medicine and Surgery: n=4; Biology and Biotechnology n=24)

 
ultimo aggiornamento: 18-Lug-2017
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