Gruppo Cirri
Research Team’s name
Cancer PAracrine signalling and Cellular Interplay
CaPACI
Coordinator
Paolo Cirri, Full Professor of Biochemistry
+39 055 2751251
Brief Biographical sketch of the Coordinator
1989 - Master Degree in Biology, University of Firenze
1993 - Diplomate Post-graduate School in Biochemistry and Clinical Chemistry, University of Firenze
1999 - PhD in Biochemistry, University of Firenze
Member of the Scientific Board the Doctorate/PhD Program in
Biochemistry and Molecular Biology
Member of the following Scientific Societies
Società Italiana di Biochimica e Biologia Molecolare (SIB)
Research Team
Anna Caselli, Associate Professor of Biochemistry
Paolo Paoli, Associate Professor of Biochemistry
Maria Letizia Taddei, Associate Professor of Molecular Biology
Alice Santi, Research Technician
Erica Pranzini, Postdoctoral Scientist
Massimo Genovese, PhD student
Ilaria Nesi, PhD student
Current research interest
New strategy for the treatment of solid tumors with targeted immunotherapy
Precision nutrition with olive pomace oil: modulation of the metabolism of dairy cows for the production of novel nutraceutical dairy products
Identification and characterization of new natural products with antidiabetic and anticancer activity
Evaluation of the role of tyrosine phosphatases in promoting cancer cell proliferation, in inducing resistance to chemo- and radiotherapy, and in regulating the activity of the cells of the tumor microenvironment
The impact of endocrine chemical disruptors on the activity of protein tyrosine phosphatases
Characterization of the role of fatty acids in regulating the activity of tyrosine phosphatases in adipocytes
The impact of the free amino acid profile of the plasma in sexually dysmorphic incidence of cancer-induced cachexia
Key words
Tumor microenvironment; Intercellular communication; Extracellular vesicles; Tumor metabolism and chemoresistance; Cell signalling; Drug discovery; Nanotechnology; Proteomics; Protein tyrosine phosphatases; Diabetes.
Current/Recent Sources of Funding
Agenzia Spaziale Italiana (ASI)
nbsp; Fondi Ateneo ex 60%
AIRC/Ente Cassa di Risparmio di Firenze
MIPAAF (Ministero delle politiche agricole alimentari e forestali)
sp; MIUR (Progetto Dipartimenti di Eccellenza 2018-2022 allocato presso il Dipartimento di Scienze Biomediche Sperimentali e Cliniche “Mario Serio”)
10 Best Publications of the last 5 years
1: Toti A, Santi A, Pardella E, Nesi I, Tomasini R, Mello T, Paoli P, Caselli A, Cirri P. Activated fibroblasts enhance cancer cell migration by microvesicles-mediated transfer of Galectin-1. J Cell Commun Signal. 2021 Sep;15(3):405-419. doi: 10.1007/s12079-021-00624-4. Epub 2021 May 22. PMID: 34021474;
2: Genovese M, Nesi I, Caselli A, Paoli P. Natural α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors: A Source of Scaffold Molecules for Synthesis of New Multitarget Antidiabetic Drugs. Molecules. 2021 Aug 9;26(16):4818. doi: 10.3390/molecules26164818. PMID: 34443409;
3: Leo A, Pranzini E, Pietrovito L, Pardella E, Parri M, Cirri P, Bruno G, Calvani M, Peppicelli S, Torre E, Sasaki M, Yang L, Zhu L, Chiarugi P, Raugei G, Arbiser JL, Taddei ML. Claisened Hexafluoro Inhibits Metastatic Spreading of Amoeboid Melanoma Cells. Cancers (Basel). 2021 Jul 15;13(14):3551. doi: 10.3390/cancers13143551. PMID: 34298765;
4: Taddei ML, Pardella E, Pranzini E, Raugei G, Paoli P. Role of tyrosine phosphorylation in modulating cancer cell metabolism. Biochim Biophys Acta Rev Cancer. 2020 Dec;1874(2):188442. doi: 10.1016/j.bbcan.2020.188442. Epub 2020 Oct 2. PMID: 33017632;
5: Pranzini E, Pardella E, Paoli P, Fendt SM, Taddei ML. Metabolic Reprogramming in Anticancer Drug Resistance: A Focus on Amino Acids. Trends Cancer. 2021 Aug;7(8):682-699. doi: 10.1016/j.trecan.2021.02.004. Epub 2021 Mar 15. PMID: 33736962;
6: Lori G, Cecchi L, Mulinacci N, Melani F, Caselli A, Cirri P, Pazzagli L, Luti S, Mazzoli L, Paoli P. Honey extracts inhibit PTP1B, upregulate insulin receptor expression, and enhance glucose uptake in human HepG2 cells. Biomed Pharmacother. 2019 May;113:108752. doi: 10.1016/j.biopha.2019.108752. Epub 2019 Mar 27. PMID: 30927676;
7: Pranzini E, Leo A, Rapizzi E, Ramazzotti M, Magherini F, Giovannelli L, Caselli A, Cirri P, Taddei ML, Paoli P. miR-210-3p mediates metabolic adaptation and sustains DNA damage repair of resistant colon cancer cells to treatment with 5-fluorouracil. Mol Carcinog. 2019 Dec;58(12):2181-2192. doi: 10.1002/mc.23107. Epub 2019 Aug 29. PMID: 31468617;
8: Leri M, Rebuzzini P, Caselli A, Luti S, Natalello A, Giorgetti S, Marchese L, Garagna S, Stefani M, Paoli P, Bucciantini M. S-Homocysteinylation effects on transthyretin: worsening of cardiomyopathy onset. Biochim Biophys Acta Gen Subj. 2020 Jan;1864(1):129453. doi: 10.1016/j.bbagen.2019.129453. Epub 2019 Oct 29. PMID: 31676294;
9: Lori G, Gamberi T, Paoli P, Caselli A, Pranzini E, Marzocchini R, Modesti A, Raugei G. LMW-PTP modulates glucose metabolism in cancer cells. Biochim Biophys Acta Gen Subj. 2018 Dec;1862(12):2533-2544. doi: 10.1016/j.bbagen.2018.08.003. Epub 2018 Aug 4. PMID: 30251652
10: Lori G, Paoli P, Caselli A, Cirri P, Marzocchini R, Mangoni M, Talamonti C, Livi L, Raugei G. Targeting LMW-PTP to sensitize melanoma cancer cells toward chemo- and radiotherapy. Cancer Med. 2018 May;7(5):1933-1943. doi: 10.1002/cam4.1435. Epub 2018 Mar 24. PMID: 29573568.
Collaborations
- CISM Mass Spectrometry Center, University of Firenze
- Professor M.M. D’Elios, Department of Experimental and Clinical Medicine, University of Firenze; Interdisciplinary Internal Medicine Unit, Careggi Hospital, Firenze;
- Dr. Richard Tomasini, Cancer Research Center of Marseille;
- Professor Rosanna Maccari and Professor Rosaria Ottanà, Department of Chemical, Biological Pharmaceutical and Environmental Sciences, University of Messina;
- Professor Antonella Del Corso, Department of Biology, Biochemistry Unit, University of Pisa;
- Professor Marialuisa Menna, Department of Pharmacy, University of Napoli Federico II;
- Professor Stefano Cicchi, Department of Chemistry “Ugo Schiff”, University of Firenze;
- nbsp; Professor Francesca Cardona, Department of Agricultural, Food, Environmental and Forestry Sciences and Technologies, University of Firenze.
Ultimo aggiornamento
03.12.2021