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SBSC Dipartimento di Scienze Biomediche Sperimentali e Cliniche

Gruppo Raugei

Coordinator of Research Team

 

Name GIOVANNI  RAUGEI

Position: Full Professor in Molecular Biology

Name of Research Team/Laboratory:   Lab. Raugei

e-mail: Giovanni.raugei@unifi.it

telephone number 055 2751202

 

 

Brief biographical sketch of the Coordinator

Born in Florence, Italy, October 7th 1953; graduated in Biology in 1978 at the University of Florence, Italy.

 

Member of the scientific board of the

Tuscany Region Pegaso PhD School in Biochemistry and Molecular Biology

 

Member of the following Scientific Societies

1) SIBBM (Società Italiana di Biofisica e Biologia molecolare)

            2) SIB (Società Italiana di Biochimica)

 

Research Team

            1) Giulia Lori, Degree in Biology, PhD in Biochemistry and Molecular Biology.

 

Current research interests 

Role of LMW-PTP (Low Molecular Weight Protein Tyrosine Phosphatase) in tumor progression and in the metabolic reprogramming of tumor cells.

 

Current / recent sources of funding

            1) Fondi di Ateneo

 

 

10    best publications of the last 5 years

 

1)      LMW-PTP as a new modulator of oxidative metabolism in cancer cells. 

Lori G. et al  and Raugei G.        In preparation

 

2)      Targeting  LMW-PTP with Morin enhances cell sensitivity towards chemotherapeutic agents and irradiation.

Lori G* et al  and Raugei G*.      In preparation

 

3)      Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.

Giannoni E, Taddei ML, Morandi A, Comito G, Calvani M, Bianchini F, Richichi B, Raugei G, Wong N, Tang D, Chiarugi P.   Oncotarget. 2015 Sep 15;6(27):24061-74.

 

4)      Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness.

Taddei ML, Giannoni E, Raugei G, Scacco S, Sardanelli AM, Papa S, Chiarugi P.

J Signal Transduct. 2012;2012:684592. doi: 10.1155/2012/684592.

 

Previous research experiences

 

1980-81: at the Max Planck Inst. fur Molekulare Genetic (Berlino, Germany); he studies the reaction of a Phycomyces to blue light.

1982-85: at EMBL (Heidelberg, Germania) he works on cloning of several human liver-specific genes and on the study of their transcriptional control.

1985-92: at Centro Ricerche Sclavo (Siena, Italy) he studies the regulation of human genes for interleukin 1 and lipocortins.

Starting Nov. 1992, at the Biochemical Sciences Dpt. ( Unifi); he studies different phosphomonohydrolases, in particular LMW-PTP, contributing to elucidate the mechanism of action of this tyrosine phosphatase. Later on he addressed his research activity on cell biology, contributing to the definition of the role of LMW-PTP in the control of cell proliferation and adhesion, demonstrating how this phosphatase has multiple substrates in the cell. More in general he was interested in the role of ROS as second messenger in cellular signalling. More recently his interests were focused on the redox regulation of oxidant-sensitive proteins during cell proliferation and adhesion to extracellular matrix. In the last years his more specific research line is dedicated to the clarification of the oncogenic role of LMW-PTP, either in model systems (cell culture and nude mice) or with epidemiological studies on several kind of human tumors. These researches led to define LMW-PTP as a new oncogene, frequently over-expressed in different human tumors and in rat colon carcinoma. At present his research is focused on the study of the mechanisms of action of different LMW-PTP inhibitors, potentially very interesting for new therapeutic approaches in tumor treatment.

 

Main scientific contributions in the last years

- Definition of the oncogenic potential of LMW-PTP overexpression

- Discovery of a potent LMW-PTP inhibitor to be possibly used in tumor thetapy

 

Collaborations

Prof. Colantuoni, (Unisannio)

Prof. Mini, D'Elios, Caderni, Mangoni, Modesti (Unifi)

 

Other relevant information

 

Links

http://www.unifi.it/cercachi-per-3774.html

http://www.unifi.it/cercachi-str-058515.html

 
ultimo aggiornamento: 28-Giu-2017
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