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SBSC Dipartimento di Scienze Biomediche Sperimentali e Cliniche

Gruppo Lolli

Coordinator of Research Team

Name Francesco Lolli

Position (Associate Professor) Scienze Tecniche Mediche

Name of Research Team/Laboratory Clinical Neurophysiology

e-mail Francesco.lolli@unifi.it

telephone number 0552758420


Brief biographical sketch of the Coordinator

PERSONAL DATA Born in Florence in 1958. PRESENT APPOINTMENT: Associate Professor of Medical technological sciences at the Faculty of Medicine of the University of Florence, HIGHER EDUCATION: In 1983, he graduated cum laud in Medicine (“MD”) at the University of Florence. Thesis entitled “Polymorphonuclear neutral proteases in experimental allergic encephalomyelitis (EAE): an experimental study”. DEGREES, DIPLOMAS AND HONORS: In 1991 he specialized in Neurology cum laud with a thesis entitled “Central Nervous system HIV infection and B and T cells alterations”. Published by the Marchi foundation in the “Collana Studi”, L. Olschki eds. (Firenze). In 1992, he obtained a phD Degree at the Karolinska Institute (Stockholm, Sweden). Thesis: “Intrathecal Synthesis of Immunoglobulins and Immune Alterations in Multiple Sclerosis and HIV infection”.

Member of the scientific board of the Doctorate/PhD Program in Neuroscience

Member of the following Scientific Societies

1) Società italiana di Neurologia

2) Associazione italiana di Neuroimmunologia

Member of the editorial board of the following Journals

1) Current protein and peptide science, Bentham Science Publisher

2) Current proteomics, Bentham Science Publisher,

Research Team

1) Lolli Francesco

2) Marinella Marinoni

3) Antonello Grippo

4) Aldo Amantini

5) Giovanni Lanzo

6) Antonella Cramaro

7) Sara Trapani

Current research interests 1. New methodologies in the study of the intrathecal synthesis of immunoglobulins and immunological factors in the central and peripheral nervous system demyelinating diseases. Innovative studies of different immunoglobulin classes, CSF free immunoglobulin light chain, complement factors, beta-2-microglobulin, anti-myelin and anti glicolipid antibodies, cytokines. 2. Pathogenetic autoimmune mechanism in central and peripheral nervous system diseases such as Multiple Sclerosis, HIV infections, Guillain-Barré syndrome, CIDP, Multifocal Motor Neuropathy, SLE, polymyositis, rheumatoid arthritis, menigoencephalithis, neurosyphilis, bacterial meningitis and Lyme disease. Immune alterations of bone marrow transplants. 3. Innovative methodologies to the functional study of a single cell (ELISPOT) 4. Innovative neurophysiological studies of CSF dynamics, central and peripheral nervous system infectious and demyelinating diseases. 5. Immune activity of immune suppressant drugs and other immunologic therapies (plasma-exchange, photopheresis, Ig infusion) in animal models and in humans. These studies brought to the identification of specific mechanisms of action of consolidated therapies and testing of new therapeutic possibility. 6. Studies identifying new conformational autoantigens in the demyelinating pathology of the nervous system. 7. Development and validation of synthetic antigens with a diagnostic value the Multiple Sclerosis. This original approach lead to the chemical synthesis of a peptide capable to identify autoantibody response in the Multiple Sclerosis.

Current / recent sources of funding

1. OTT, organizzazione Toscana Trapianti

2. Università degli Studi di Firenze

3. Azienda Ospedaliera di Careggi CTO

 10 best publications of the last 5 years

1: Cesaretti C, Molesti E, Lolli F, Amantini A, Lori S. O034. Type of pain and

onabotulinumtoxin-A in chronic migraine: four years of follow-up. J Headache

Pain. 2015 Dec;16(Suppl 1):A89. doi: 10.1186/1129-2377-16-S1-A89. PubMed PMID:

28132299; PubMed Central PMCID: PMC4715029.

2: Walvoort MT, Testa C, Eilam R, Aharoni R, Nuti F, Rossi G, Real-Fernandez F,

Lanzillo R, Brescia Morra V, Lolli F, Rovero P, Imperiali B, Papini AM.

Antibodies from multiple sclerosis patients preferentially recognize

hyperglucosylated adhesin of non-typeable Haemophilus influenzae. Sci Rep. 2016

Dec 23;6:39430. doi: 10.1038/srep39430. PubMed PMID: 28008952.

3: Scarpino M, Lanzo G, Carrai R, Lolli F, Migliaccio ML, Spalletti M, Peris A,

Amantini A, Grippo A. Predictive patterns of sensory evoked potentials in

comatose brain injured patients evolving to brain death. Neurophysiol Clin. 2016

Dec 16. pii: S0987-7053(16)30204-0. doi: 10.1016/j.neucli.2016.11.001. [Epub

ahead of print] PubMed PMID: 27993450.

4: Peroni E, Real Fernández F, Gheri C, Nuti F, Mitaine-Offer AC, Lolli F,

Lacaille-Dubois MA, Papini AM. Triterpene glycosides from plants for antibody

recognition. Planta Med. 2016 Dec;81(S 01):S1-S381. PubMed PMID: 27975684.

5: Scarpino M, Lolli F, Carrai R, Lanzo G, Spalletti M, Barilaro A, Fattapposta

F, Amantini A, Grippo A. Diagnostic accuracy of neurophysiological criteria for

early diagnosis of AIDP: A prospective study. Neurophysiol Clin. 2016

Feb;46(1):35-42. doi: 10.1016/j.neucli.2015.12.008. PubMed PMID: 26906685.

6: Real-Fernández F, Rossi G, Lolli F, Papini AM, Rovero P. Label-free method for

anti-glucopeptide antibody detection in Multiple Sclerosis. MethodsX. 2015 Mar

12;2:141-4. doi: 10.1016/j.mex.2015.03.004. PubMed PMID: 26150982; PubMed Central

PMCID: PMC4487706.



7: Real Fernández F, Di Pisa M, Rossi G, Auberger N, Lequin O, Larregola M,
Benchohra A, Mansuy C, Chassaing G, Lolli F, Hayek J, Lavielle S, Rovero P,
Mallet JM, Papini AM. Antibody recognition in multiple sclerosis and Rett
syndrome using a collection of linear and cyclic N-glucosylated antigenic probes.
Biopolymers. 2015 Sep;104(5):560-76. doi: 10.1002/bip.22677. PubMed PMID:
25973844.

8: Niccheri F, Real-Fernàndez F, Ramazzotti M, Lolli F, Rossi G, Rovero P,
Degl'Innocenti D. Human recombinant domain antibodies against multiple sclerosis
antigenic peptide CSF114(Glc). J Mol Recognit. 2014 Oct;27(10):618-26. doi:
10.1002/jmr.2386. PubMed PMID: 25178857.

9: Lolli F, Martini H, Citro A, Franceschini D, Portaccio E, Amato MP, Mechelli
R, Annibali V, Sidney J, Sette A, Salvetti M, Barnaba V. Increased CD8+ T cell
responses to apoptotic T cell-associated antigens in multiple sclerosis. J
Neuroinflammation. 2013 Jul 27;10:94. doi: 10.1186/1742-2094-10-94. PubMed PMID:
23890271; PubMed Central PMCID: PMC3734107.

10: Stipa G, Manganelli M, Lolli F. Cyanobacteria biomagnification and
amyotrophic lateral sclerosis. Med Hypotheses. 2013 Aug;81(2):356-7. doi:
10.1016/j.mehy.2013.04.039. PubMed PMID: 23673195.

11: Chanson JB, Paolini I, Collongues N, Alcaro MC, Blanc F, Barbetti F, Fleury
M, Peroni E, Rovero P, Rudolf G, Lolli F, Trifilieff É, Papini AM, de Seze J.
Evaluation of new immunological targets in neuromyelitis optica. J Pept Sci. 2013
Jan;19(1):25-32. doi: 10.1002/psc.2470. PubMed PMID: 23193094.

12: Pandey S, Dioni I, Lambardi D, Real-Fernandez F, Peroni E, Pacini G, Lolli F,
Seraglia R, Papini AM, Rovero P. Alpha actinin is specifically recognized by
Multiple Sclerosis autoantibodies isolated using an N-glucosylated peptide
epitope. Mol Cell Proteomics. 2013 Feb;12(2):277-82. doi:
10.1074/mcp.M112.017087. PubMed PMID: 23139387; PubMed Central PMCID: PMC3567853.

13: Real-Fernández F, Passalacqua I, Peroni E, Chelli M, Lolli F, Papini AM,
Rovero P. Glycopeptide-based antibody detection in multiple sclerosis by surface
plasmon resonance. Sensors (Basel). 2012;12(5):5596-607. doi: 10.3390/s120505596.
PubMed PMID: 22778603; PubMed Central PMCID: PMC3386702.
Previous research experiences
PhD Neuroimmunology
 
Main scientific contributions
Study of the intrathecal synthesis of immunoglobulins and immunological factors in the central and peripheral nervous system demyelinating diseases. Innovative studies of different immunoglobulin classes, CSF free immunoglobulin light chain, complement factors, beta-2-microglobulin, anti-myelin and anti glicolipid antibodies, cytokines. Pathogenetic autoimmune mechanism in central and peripheral nervous system diseases such as Multiple Sclerosis, HIV infections, Guillain-Barré syndrome, CIDP, Multifocal Motor Neuropathy, SLE, polymyositis, rheumatoid arthritis, menigoencephalithis, neurosyphilis, bacterial meningitis and Lyme disease. Immune alterations of bone marrow transplants. Innovative methodologies to the functional study of a single cell (ELISPOT) 4. Innovative neurophysiological studies of CSF dynamics, central and peripheral nervous system infectious and demyelinating diseases. Studies identifying new conformational autoantigens in the demyelinating pathology of the nervous system.  Development and validation of synthetic antigens with a diagnostic value the Multiple Sclerosis
 
Collaborations
 
AOUC, SOD Neurofisiopatologia 
ultimo aggiornamento: 18-Lug-2017
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