Gruppo Mannucci

Research Team’s name: Diabetes and Metabolism


Coordinator: Edoardo Mannucci


Brief Biographical sketch of the Coordinator: Born in Prato, Italy, in 1965, E.M. graduated from Florence Medical School in 1990 and received his post-graduate degree in Endocrinology in Florence, in 1995. He worked as Diabetologist in the Geriatric Unit of Careggi Hospital, Florence, from 2004 to 2009, and he directed the Diabetes Agency of Careggi Hospital from 2009 to 2015. Since 2015, he is Associate Professor of Endocrinology at the University of Florence and Director of the Division of Diabetology and Metabolic Diseases of Careggi Hospital.


Member of the Scientific Board of the Doctorate/Phd Program

Endocrine, Molecular and Regenerative Sciences of the University of Florence.


Member of the following Scientific Societies:

 Italian Society of Diabetology, Italian Association of Diabetologists, Italian Society of Obesity.


Member of editorial board of the following Journals:

Acta Diabetologica, Aging Clinical and Experimental; Journal of Endocrinological Investigation


Research Team

Claudia Cosentino,  Research fellow, Careggi Hospital

Barbara Cresci, Diabetologist, Careggi Hospital

Ilaria Dicembrini, Researcher (RTDB), University of Florence

Stefano Giannini, Diabetologist, Careggi Hospital

Matteo Monami, Diabetologist, Careggi Hospital

Laura Pala, Diabetologist, Careggi Hospital

Maria Pieri, Diabetologist, Careggi Hospital

Benedetta Ragghianti, Diabetologist, Careggi Hospital

Federica Santagiuliana, Dietitian, Careggi Hospital

Antonio Silverii, Research fellow, University of Florence

Valentina Vitale, Diabetologist, Careggi Hospital


Current research interests

Outcome research on pharmacological treatment of type 2 diabetes

Educational programs for the treatment of type 2 diabetes, obesity, and diabetic foot

Development of strategies for the use of technology in the monitoring and treatment of type 1 diabetes

Development of local treatments for diabetic foot ulcers

Screening and clinical definition of diabetic retinopathy


Key words

Diabetes, Obesity, Diabetic foot, Diabetic retinopathy

Current/recent sources of funding

Tuscany Region grant for studies on precision medicine

Nonconditional grants from Abbott and Mimetech

Fees from sponsored clinical trials

10 best publications of the last 5 years

Bellini B, Cresci B, Cosentino C, Profili F, Bartolacci S, Scoccimarro D, Voller F, Balzi D, Francesconi P, Mannucci E. Obesity as a risk factor for hospitalization in COronaVirus Disease-19 (COVID-19) patients: Analysis of the Tuscany regional database. Nutr Metab Cardiovasc Dis 2020 Dec 8:S0939-4753(20)30507-X. doi: 10.1016/j.numecd.2020.11.030. [Epub ahead of print].

Monami M, Ragghianti B, Silverii A, Scatena A, Landi L, Cosentino C, Vitale V, Mannucci E. Retrospective Matched Case-Control Study on the Use of CO2Laser for the Treatment of Nonhealing Diabetic Foot Ulcers: The DULCIS-2 (Diabetic ULcer, CO2 Laser, and Infections) Study. Int J Low Extrem Wounds  2020 Nov 23:1534734620960298. doi: 10.1177/1534734620960298. [Epub ahead of print].

Dicembrini I, Pala L, Caliri M, Minardi S, Cosentino C, Monami M, Mannucci E. Combined continuous glucose monitoring and subcutaneous insulin infusion versus self-monitoring of blood glucose with optimized multiple injections in people with type 1 diabetes: A randomized crossover trial. Diabetes Obes Metab  22: 1286-91, 2020. doi: 10.1111/dom.14028

Cresci B, Cosentino C, Monami M, Mannucci E. Metabolic surgery for the treatment of type 2 diabetes: A network meta-analysis of randomized controlled trials. Diabetes Obes Metab  22: 1378-87, 2020. doi: 10.1111/dom.14045.

Silverii GA, Dicembrini I, Monami M, Mannucci E. Fournier's gangrene and sodium-glucose co-transporter-2 inhibitors: A meta-analysis of randomized controlled trials. Diabetes Obes Metab 22: 272-275. doi: 10.1111/dom.13900.

Dicembrini I, Serni L, Monami M, Caliri M, Barbato L, Cairo F, Mannucci E. Type 1 diabetes and periodontitis: prevalence and periodontal destruction-a systematic review. Acta Diabetol  57: 1405-12, 2020. doi: 10.1007/s00592-020-01531-7.

Cantini G, Trabucco M, Di Franco A, Mannucci E, Luconi M. Glucagon modulates proliferation and differentiation of human adipose precursors. J Mol Endocrinol 63: 249-260, 2019.

Dicembrini I, Mannucci E, Monami M, Pala L. Impact of technology on glycaemic control in type 2 diabetes: A meta-analysis of randomized trials on continuous glucose monitoring and continuous subcutaneous insulin infusion. Diabetes Obes Metab  21: 2619-2625, 2019.

Monami M, Scatena A, Zannoni S, Aleffi S, Mirabella C, Giannoni L, Mannucci E. A randomized, open-label, controlled trial to evaluate the antimicrobial and surgical effect of CO2 laser treatment in diabetic infected foot ulcers: DULCIS (diabetic ulcer, CO2 laser, and infections) study. J Endocrinol Invest  40: 985-989, 2017.

Nauck MA, Petrie JR, Sesti G, Mannucci E, Courrèges JP, Lindegaard ML, Jensen CB, Atkin SL; Study 1821 Principal Investigators. A Phase 2, Randomized, Dose-Finding Study of the Novel Once-Weekly Human GLP-1 Analog, Semaglutide, Compared With Placebo and Open-Label Liraglutide in Patients With Type 2 Diabetes. Diabetes Care 39: 231-241, 2016.

Previeus research experiences

The coordinator and the other members of the group have previous experience on microvascular endothelial cells as a model for the in vitro study of diabetic microangiopathy; gene therapy of rodent models of diabetes with genes codifying for GLP1 analogues; in vivo assessment of the impairment of GLP1 axis in the pathogenesis of type 2 diabetes; development of psychometric instruments for the study of quality of life and well-being in diabetes and obesity; assessment of the psychological profile of patients with obesity, type 1 and type 2 diabetes, and eating disorders; association of different diabetes treatment with incident cancer.



Ophtalmology, Department of Neurosciences, University of Florence

Cardiology, Department of Experimental and Clinical Medicine, University of Florence

Dentistry, Department of Experimental and Clinical Medicine, University of Florence

Tuscany Regional Health Agency (Agenzia Regionale di Sanità)

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