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SBSC Dipartimento di Scienze Biomediche Sperimentali e Cliniche

Gruppo Meacci

Coordinator of Research Team

 

Name…………      Prof   ELISABETTA MEACCI …………………………………………………………………….

Position (Associate Professor of Molecular Biology…   Bio/11…………………………………………………

Name of Research Team/Laboratory ……Unit of Molecular and Applied Biology…………………………………

e-mail……elisabetta.meacci@unifi.it………………………………………………………………………………………….

telephone number……00390552751231…………………………………………………………………………..

 

 

Brief biographical sketch of the Coordinator (date of birth, degrees and Universities where they have been obtained)

 

Pistoia (Italy), February 20, 1963

EDUCATION

 1987 Degree in Biological Sciences cum laude at the University of Firenze.

1989  Post-graduated studies in Phamacology (Specializzazione in Farmacologia) magna cum laude at the University of Firenze;

1989-1992  Fogarty/NIH Visiting Fellows at the National Heart, Lung and Blood Institutes/Laboratory of Cellular Metabolism (NHLBI/LCM) at the National Institutes of Health of Bethesda (NIH, MD, USA) in the laboratory coordinated by Dr. Vincent Manganiello. During this period, she participated to molecular biology studies aimed to characterize cAMP-specific phosphodieterase.

1992-1996  Ph.D in Biochemistry  Department of Biochemical Sciences Univ of Firenze

1996  National Research Council Fellowship

1996-1998  Fogarty/ NIH Visiting Associate in the laboratory coordinated by Dr. Joel Moss, Chief of Pulmonary-Critical Care Medicine Branch, National Heart, Lung and Blood Institute of the NIH. During this period her research was focused on cytohesin-1,a guanine nucleotide exchange factor specific for monomeric GTP-binding proteins of ARF family.

1998  Researcher (Biochemistry, BIO/10) at the Faculty of Sciences of the University of Firenze.

2002 she was positively evaluated as Associate Professor (Molecular Biology, BIO/11) in a comparative "concorso" at the Faculty of Sciences of the University of Modena and Reggio Emilia.

From 2005 she start teaching as Associate Professor (Molecular Biology, BIO/11) at the Faculty of Sciences

From 2012  she obtained the Abilitazione Nazionale to Full Professor in 05/E Biochemistry and Molecualr Biology ASN 2012  .

From 2012  she obtained the Abilitazione Nazionale to Full Professor in 05/F Applied Biology (Bio/13) ASN 2012.

 

From 2008 to 2012:  Coordinator (Presidente) of the Master Course in Molecular Biotechnologies

From 2010 at present:  Delegate of the Faculty of Science  for Job Placement/CsaVRI at the University of Firenze.

2006-2011 Member of the Scientific Board of the PhD in  "Biomedical Sciences- Biochemistry and Applied Biology”

2011 at present  Member of the Scientific Board of the PhD in  "Biomedical Sciences”

2013 at present - Delegate of the University of Florence for “Apprendistato di Alta formazione e ricerca” CsaVRI.

2017 at present Delegate of the Department of Experimental and Clinical Biomedical Sciences for Centro di Servizi di Ateneo per la Valorizzazione della Ricerca e la gestione dell'Incubatore universitario (CsaVRI

 

Teaching activities – Courses-

- Molecular Biology in basic and advanced courses  for students of Laurea Triennale e Magistrale in Molecular Biotechnology , Laurea Triennale e Magistrale in Biology and Master in School of Specialists Studies in Health area at the University of Firenze.

- Biochemistry in basic and advanced courses  for students of Laurea Triennale e Magistrale in Biotechnology , Laurea Triennale e Magistrale in Biology

- Organism model in biology in Laurea Magistrale in Molecular Biotechnology

- Biomolecular technologies  for students of Laurea Magistrale in Molecular  Biotechnology

 

 

Member of the scientific board of the Doctorate/PhD Program in

 

2006- 2010 PhD in Biochemistry and Applied Biology – University of Firenze

2011 to present PhD in Biomedical Sciences – University of Firenze

 

Member of the following Scientific Societies

1) SIB Societa Italiana di Biochimica e Biologia Molecolare……………………………..

                2) ABCD Associazione di Biologia cellulare e del Differenziamento …………………………................

                3) SIPMel  Società italiana di Patologia Clinica e Medicina di laboratorio

 

Member of the editorial board of the following Journals

1) Editorial Board member of AIMS Molecular Science (Prof. Owen M. McDougal,  Editor in Chief of AIMS Molecular Science, Boise State University,  USA 

2) Assistant Editor of “International Scholarly Research Network (ISNR) Cell Biology Hindawi Publishing Corporation. 

 

Research Team

                1) Alessia Frati, Master  in Biology, Specialist in Clinical Biochemistry

                2) Federica Pierucci, Master in Biology, PhD in Biomedical Sciences

                3) Ambra Vestri, Master in Molecualr Biotecnology, PhD in Biotecnology

 

Current research interests 

 

Research interests

In the last 15 years her research has been focused on the sphingolipid metabolism, the signalling pathways triggered by sphingosine 1-phosphate in various mammalian cell types (muscle and cardiac cells and tumoral cells) and on the regulation of enzymes involved in the control of cellular levels of lipid mediators, such as phospholipase D, sphingomyelinase and ceramidase.

More recently, her research has been also focus on the role of Connexin 43, Gap junction communication and Stretch-activated channels (TRCP) in cell proliferation and myogenesis in skeletal muscle satellite cells..

 In the last year, her reaserch has been finalized to the nantechonology field:   identification of new protocols for nanoparticles from plants. and phage display library for nanoantibodies production

She is coauthor of 71  publications on international journals and she participated at 118  national and international congresses, also as invited speaker. DATI SCOPUS  Contemporary H- index:  20

 

Current / recent sources of funding

                1) …MIUR…- PRIN……………………

                2) …Regione Toscana………………………………………………………………………………………...

                3) .. Ente Cassa di Risparmio di Firenze…………………………………

               4) …Fondazione Cassa di risparmio di Pistoia e Pescia…………………………

               5)  …Fondazione Banca di Pistoia e Vignole……………………………

 

10 best publications of the last 5 years

 

 C.Sassoli, L.Formigli, F.Bini, A.Tani, R.Squecco, C.Battistini, S.Zecchi-Orlandini,F.Francini, E.Meacci

Effects of S1P on skeletal muscle repair/regeneration during eccentric contraction

 J Cell Mol Med. 2012 Nov;15(11):2498-511

 

 E.Meacci, F.Bini and C.Battistini  S1P Signaling in Skeletal Muscle Cells.

Methods in Molecular Biology (2012) 874:155-165

 

F.Bini, A.Frati, M.Garcia-Gil, C.Battistini, M.Granado, M.Martinesi, Mainardi M., Vannini E., Luzzati F., Caleo M., Peretto P., A.Gomez -Muñoz and E.Meacci

 New signalling pathway involved in the antiproliferative action of Vitamin D3 and its structural analogues in human neuroblastoma cells. A role for ceramide kinase/ceramide 1-phosphate axis. 

Neuropharmacology (2012) 63(4): 524-37.

 

A.Frati, D.Berti, C.Marinelli, C.Battistini, L.Fontana, G.Anderloni, M.Migliorini, M.Garcia Gil, E.Meacci

Nutraceutical properties of tuscany chestnut flours: beneficial effects on skeletal muscle atrophy. 

Food and Function  2014 5, 2870-2882

 

C.Sassoli*, A. Frati*, A.Tani, G. Anderloni, F. Pierucci, F.Matteini, F. Chellini, S. Zecchi Orlandini, L. Formigli, E. Meacci    *equally contributed Mesenchymal stromal cell secreted sphingosine 1-phosphate (S1P) exerts a stimulatory effect on skeletal myoblast proliferation.

PLOS ONE (2014)  9(9):e108662. doi: 10.1371/journal.pone.0108662. eCollection 2014.

 

  1. A.      Frati, B.Ricci, F.Pierucci, S.Nistri, D.Bani, E.Meacci

Role of sphingosine kinase/s1p axis in ecm-remodeling of cardiac cells elicited by the  hormone relaxin.

 Mol Endocrinol (2015) 29:53-67. doi: 10.1210/me.2014-1201. 

 

F.Pierucci , A.Frati, R.Squecco, E.Lenci, C.Vicenti, J.Slavik, F.Francini, M.Machala, E.Meacci 

Non-dioxin-like organic toxicant PCB153 alters Cx43-formed Gap junction function in liver progenitor cells  through the modulation of sphingolipid metabolism .  

Arch Toxicol. 2017 91:749-760. doi: 10.1007/s00204-016-1750-7.

 

F.Pierucci, M.Garcia-Gil, A.Frati, E. Bruzzone, B.Ricci, E. Vannini, F. Luzzati, M. Caleo, P. Peretto, E. Meacci 

Vitamin D3 protects against amyloid 42 peptide cytotoxicity in differentiated human neuroblastoma SH-SY5Y cells: a role for S1P/S1P1 axis.

Neuropharmacology (2017) 116:328-342. doi: 10.1016/j.neuropharm.2017.01.003. [Epub ahead of print] 

 

M.Garcia-Gil,  F. Pierucci, A. Vestri, E. Meacci 

Crosstalk between sphingolipids  and  vitamin D3: potential role in the nervous system. Review 

Br J Pharmacol. 2017 Jan 27. doi: 10.1111/bph.13726. [Epub ahead of print] Review.

 

Previous research experiences ………………………………………………………………………………………………………………………………………………………………………1989-1992  Fogarty/NIH Visiting Fellows at the National Heart, Lung and Blood Institutes/Laboratory of Cellular Metabolism (NHLBI/LCM) at the National Institutes of Health of Bethesda (NIH, MD, USA) in the laboratory coordinated by Dr. Vincent Manganiello. During this period, she participated to molecular biology studies aimed to characterize cAMP-specific phosphodieterase.

1992-1996  Ph.D in Biochemistry  Department of Biochemical Sciences Univ of Firenze

1996  National Research Council Fellowship

1996-1998  Fogarty/ NIH Visiting Associate in the laboratory coordinated by Dr. Joel Moss, Chief of Pulmonary-Critical Care Medicine Branch, National Heart, Lung and Blood Institute of the NIH. During this period her research was focused on cytohesin-1,a guanine nucleotide exchange factor specific for monomeric GTP-binding proteins of ARF family.

 

 

Collaborations

S. Zecchi, UNIFI

D. Bani, UNIFI

F. Naro, Univ di Roma

M.Garcia-Gil, Univ di Pisa

M. Caleo, CNR Pisa

P. Peretto, Univ di Torino

 

………………………………………………………………………………………………………………………………………………………………………

 

Other relevant information

 

Responsabile: Meacci Elisabetta

Titolo: Unità di ricerca di biologia molecolare e biologia applicata

 

Linee di ricerca:

Identificazione dei bersagli molecolari della sfingosina 1-fosfato in cellule muscolari scheletriche: coinvolgimento nella comunicazione cellula-cellula (Connessina 43 e Gap junction), nel rimodellamento del citoscheletro e motilità cellulare.

 

 Identificazione dei bersagli molecolari degli sfingolipidi in cellule cardiache e loro ruolo nella rigenerazione tissutale. Coinvolgimento nell’azione dell’ormone relaxina

 

Ruolo biologico dell’asse ceramide/ceramide chinasi/ceramdie 1-fosfato nell’azione neuroprotettiva della vitamina D3 in cellule di neuroblastoma umano (SH-SY5Y),  nella neurodegenerazione e nella biologia muscolare

 

Coinvolgimento degli sfingolipidi nella citotossitità indotta da composti diossina-like e non dioxin-like in cellule precursori staminali di fegato (WB F344).

 

Ruolo di polifenoli (epigallocatechina, acido rosmarinico e caffeico) e principi bioattivi nella biologia delle cellule muscolari scheletriche Ricerche sulla biocompatibilità di materiali usati in campo medico e odontoiatrico.

 

Studi riguardanti il ruolo dei derivati della vitamina D nelle malattie infiammatorie croniche, tumori e neurodegenerazione

 

Sviluppo di nuovi protocolli per la messa a punto di nanoanticorpi per il biomonitoraggio e la protezione ambientale

 

Uso di C elegans come organismo modello

 

Links

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ultimo aggiornamento: 11-Lug-2017
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