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DSBSC Dipartimento di Scienze Biomediche Sperimentali e Cliniche

Gruppo Degl'Innocenti

Coordinator of Research Team

Name                                                   Donatella Degl’Innocenti

Position                                               Associate professor of biochemistry

Name of Research Team/Laboratory                      DLAb

e-mail                                   donatella.deglinnocenti @unifi.it

telephone number          055 275 1249

 

Brief biographical sketch of the Coordinator 

  • 1983: Prof. Donatella Degl’Innocenti received her Master Degree in Biological Sciences (summa cum laude) at University of Florence (Italy);
  • 1990: she obtained a Ph.D. in Biochemistry at University of Florence (Italy);
  • 1991-2001: she became a researcher at the Faculty of Pharmacy (Biochemistry sector) of the University of Florence.
  • Since 2001: she is Associate Professor of Biochemistry in the Department of Experimental and Clinical Biomedical Sciences “Mario Serio” (University of Florence). She is a lecturer in the degree courses in Medicine and Surgery, Pharmacy and Pharmaceutical Chemistry and Technology of the School of Human Health Sciences (University of Florence).
  • 2005-2006: she was nominated President of the Specialized Degree Course in “Pharmaceutical Biotechnology” of the Faculty of Pharmacy (University of Florence), confirmed also for 2009-2013 academic years.
  • Since 2008: she is a member of the Scientific Committee of the Interuniversity Center of Marine Biology and Applied Ecology (CIBM) of Livorno (Italy);
  • 2010: she was nominated member of the Interuniversity Research Center on the Molecular Bases of Neurodegenerative Diseases (CIMN) of Florence (Italy).
  • 2013-2014 and 2016-2017: she was nominated President of the Master of Science in "Medical and Pharmaceutical Biotechnology", as well as coordinator of the II level Master "Territorial pharmacist: clinical skills" (2015-2016 year).

 

 

Research Team

  1. Ramazzotti Matteo (Associate professor of Molecular Biology BIO/11)  matteo.ramazzotti@unifi.it  
  2. Eameuela Barletta   (Associate professor of Phatology  MED/04) emanuela.barletta@unifi.it
  3. Vasarri Marzia   PhD student  marzia.vasarri@stud.unifi.it;

 

Current research interests

  • Use of phage display
  • Bioactivity of natural molecules
  • Cell growth and physiology processes
  • Role of oxidative stress in rare CCHS disease

 

Publications of the last 5 years

  1. Vasarri M, Ramazzotti M, Tiribilli B, Barletta E, Pretti C, Mulinacci N, Degl’Innocenti D. The In Vitro Anti-amyloidogenic Activity of the Mediterranean Red Seaweed Halopithys Incurva. Pharmaceuticals. 2020;13:185. https://doi.org/10.3390/ph13080185.
  2. Leri M, Vasarri M, Palazzi L, Barletta E, Nielsen E, Bucciantini M, Degl'Innocenti D. Maysin plays a protective role against α-Synuclein oligomers cytotoxicity by triggering autophagy activation. Food Chem Toxicol. 2020;144:111626. DOI:10.1016/j.fct.2020.111626.
  3. Vasarri M, Barletta E, Ramazzotti M, Degl'Innocenti D. In vitro anti-glycation activity of the marine plant Posidonia oceanica (L.) Delile. J Ethnopharmacol. 2020;259:112960. doi: 10.1016/j.jep.2020.112960.
  4. Vasarri M, Leri M, Barletta E, Ramazzotti M, Marzocchini R, Degl'Innocenti D. Anti-inflammatory properties of the marine plant Posidonia oceanica (L.) Delile. J Ethnopharmacol. 2020;247:112252. doi: 10.1016/j.jep.2019.112252.
  5. Piazzini V, Vasarri M, Degl'Innocenti D, Guastini A, Barletta E, Salvatici MC, Bergonzi MC. Comparison of Chitosan Nanoparticles and Soluplus Micelles to Optimize the Bioactivity of Posidonia oceanica Extract on Human Neuroblastoma Cell Migration. Pharmaceutics. 2019;11:655. doi: 10.3390/pharmaceutics11120655.
  6. Degl'Innocenti D, Ramazzotti M, Sarchielli E, Monti D, Chevanne M, Vannelli GB, Barletta E. Oxadiazon affects the expression and activity of aldehyde dehydrogenase and acylphosphatase in human striatal precursor cells: A possible role in neurotoxicity. Toxicology. 2019;411:110-121. doi: 10.1016/j.tox.2018.10.021.
  7. Leri M, Ramazzotti M, Vasarri M, Peri S, Barletta E, Pretti C, Degl'Innocenti D. Bioactive Compounds from Posidonia oceanica (L.) Delile Impair Malignant Cell Migration through Autophagy Modulation. Mar Drugs. 2018;16:137. doi: 10.3390/md16040137.
  8. Degl'Innocenti D, Becatti M, Peruzzi M, Fiorillo C, Ramazzotti M, Nassi N, Arzilli C, Piumelli R. Systemic oxidative stress in congenital central hypoventilation syndrome. Eur Respir J. 2018;52:1801497. doi: 10.1183/13993003.01497-2018.
  9. Ramazzotti M, Paoli P, Tiribilli B, Viglianisi C, Menichetti S, Degl'innocenti D. Catechol-Containing Hydroxylated Biomimetic 4-Thiaflavanes as Inhibitors of Amyloid Aggregation. Biomimetics (Basel). 2017;2:6. doi: 10.3390/biomimetics2020006.
  10. Ramazzotti M, Melani F, Marchi L, Mulinacci N, Gestri S, Tiribilli B, Degl'Innocenti D. Mechanisms for the inhibition of amyloid aggregation by small ligands. Biosci Rep. 2016;36:e00385. doi: 10.1042/BSR20160101.
  11. Barletta E, Ramazzotti M, Fratianni F, Pessani D, Degl'Innocenti D. Hydrophilic extract from Posidonia oceanica inhibits activity and expression of gelatinases and prevents HT1080 human fibrosarcoma cell line invasion. Cell Adh Migr. 2015; 9:422-31. doi: 10.1080/19336918.2015.1008330.

 

Previous research experiences

Since the beginning of her research activity, Prof. Degl’Innocenti focused her scientific interests on acylphosphatase characterization and purification, polyclonal antibody production and gene cloning. She conducted original and stimulating research in the immunological field, dedicating herself to the selection and production of specific recombined single chain antibodies (scFv) directed against conformational epitopes by screening phage libraries. In 2014, she produced a recombinant human antibody (vhv) against Multiple Sclerosis epitopes. In recent years she actively devoted herself to the study of some aspects of congenital central hypoventilation syndrome (CCHS), a rare respiratory disease, creating an effective collaboration network with the Meyer Children's Hospital of Florence (Italy) required for the collection of biological samples from highly specialized personnel. In particular, thanks to the technical-scientific skills in biochemistry and molecular biology, Prof. Degl'Innocenti obtained excellent results on the role of oxidative stress in CCHS patients by developing systems for the evaluation of reactive oxygen species in blood cells of CCHS subjects. Prof. Degl’Innocenti also aimed her research on the study of the biological properties of extracts of the marine plant Posidonia oceanica by collaborating with the authorized staff of the CIBM (Interuniversity Center of Marine Biology and Applied Ecology) of Livorno (Italy). In particular, her studies focused on the role of these extracts on pathophysiological cellular processes, such as inflammation and oxidative stress, but also migration of cancer cells and protein glycation processes. Over the years she has also dedicated herself to the study of the amyloid aggregation process and the possible mechanisms for its inhibition.

  

Collaborations

  • Dipartimento NEUROFARBA -Università degli Studi di Firenze
  • CIBM (Centro Interuniversitario di Biologia Marina  - Livorno
  • Meyer Children's Hospital of Florence (Italy)
  • Department of Chemistry, University of Florence,  Florence,

 

Links  

http://www.unifi.it/p-doc2-2015-0-A-2b333730322a-1.html  

http://www.sbsc.unifi.it/vp-157-master.html 

 
ultimo aggiornamento: 31-Ago-2020
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