Coordinator of Research Team
Name: Emanuela Barletta MD PhD
Position: Associate Professor of General Pathology (MED/04)
Name of Research Team/Laboratory: Environmental and occupational etiology of neoplastic, degenerative and inflammatory diseases
telephone number: 055 2751284
Brief biographical sketch of the Coordinator
1985 MD degree, summa cum laude, School of medicine, University of Florence.
1988-1990 Research Associate at the laboratory of Dr. Lloyd A. Culp, Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland (Ohio, U.S.A.)
1991 PhD degree in Experimental Pathology.
1995 Diploma of Specialist in Hygene and Medical Prevention, Epidemiology and Public Health, School of Medicine, University of Florence.
1995 Ricercatore universitario, School of Medicine, University of Florence.
2005 to date Associate Professor, School of Human Health Sciences (former School of Medicine), University of Florence.
Dr. Barletta is in charge of the teaching program of General Pathology at School of Human Health Sciences, University of Florence in the following degrees: "Medicine and Surgery", first level Degrees in "Biomedical Laboratory Techniques", in "Orthopaedics Techniques", and in "Health Care Assistant".
Member of the following Scientific Societies
1) Gruppo Italiano "I Processi di ADPribosilazione"
Member of the editorial board of the following Journals
1) WebMedCentral, Webmed Limited, UK.
2) WebMedCentral plus,Webmed Limited, UK
1) Antonella Mannini, Master degree in Biological Science, PhD
Assistant Professor of General Pathology (MED/04) , University of Florence
Area of interest: role of host factors in the metastatic process and molecular mechanism involved in metastatic cascade
2) Donatella Degl’Innocenti, Master degree in Biological Science, PhD
Associate Professor of Biochemistry University of Florence
Area of interest: role of these naturally occurring compounds on pathophysiological cellular processes, such as inflammation and oxidative stress, cancer cell migration, protein glycation, autophagy and apoptosis processes.
3) Alice Verdelli MD, PhD
Rare Diseases Unit, Azienda USL Toscana Centro European Reference Network-Skin Member
Area of interest: Rare skin diseases, Connective Tissue Diseases, Cutaneous Vasculitis, Vesiculobullous Skin Diseases, Dermatitis Herpetiformis, Psoriasis, Melanoma, Basal Cell Carcinoma
4) Marzia Vasarri Master degree in Medical and Pharmaceutical Biotechnology, PhD
Fellow, University of Florence
Area of interest: investigation of bioactive properties of natural products in different in vitro and in vivo experimental models
Current research interests Dr. Barletta has focused her attention on the role of cell adhesion and invasion in autoimmune skin diseases and hidradenitis suppurativa, neurodegenerative diseases and on the role of occupational exposure to pesticides in development of neurodegenerative diseases.
Current / recent sources of funding
1) University of Florence
2) Fondazione Cassa di Risparmio di Pistoia e Pescia
Best publications of the last 5 years
Vasarri M.; Leri M.; Barletta E.; Pretti C.; Degl'innocenti D. Posidonia oceanica (L.) delile dampens cell migration of human neuroblastoma cells MARINE DRUGS (2021) 19 : 579 - 595
Vasarri M.; Barletta E.; Degl'innocenti D. Posidonia oceanica (L.) delile extract reduces lipid accumulation through autophagy activation in hepg2 cells PHARMACEUTICALS (2021) 14 : 969 - 980 DOI: 10.3390/ph14100969
Micheli L.; Vasarri M.; Barletta E.; Lucarini E.; Ghelardini C.; Degl'Innocenti D.; Di Cesare Mannelli L. Efficacy of Posidonia oceanica Extract against Inflammatory Pain: In Vivo Studies in Mice MARINE DRUGS (2021) 19 : 48 - 62 DOI:10.3390/md19020048
Donatella Degl’Innocenti, Marzia Vasarri, Emanuela Barletta An Overview of New Insights into the Benefits of the Seagrass Posidonia oceanica for Human Health MARINE DRUGS (2021) 19 : 0 - 0 DOI: 10.3390/md19090476
Vasarri M.; Leri M.; Barletta E.; Ramazzotti M.; Marzocchini R.; Degl'Innocenti D. Anti-inflammatory properties of the marine plant Posidonia oceanica (L.) Delile JOURNAL OF ETHNOPHARMACOLOGY (2020) 247 : 112252 - 112259 DOI: 10.1016/j.jep.2019.112252
Vasarri M.; Ramazzotti M.; Tiribilli B.; Barletta E.; Pretti C.; Mulinacci N.; Degl'innocenti D. The in vitro anti-amyloidogenic activity of the mediterranean red seaweed halopithys incurva PHARMACEUTICALS (2020) 13 : 1 - 15 DOI: 10.3390/ph13080185
Maria Camilla Bergonzi, Marzia Vasarri, Giulia Marroncini , Emanuela Barletta, Donatella Degl’Innocenti Thymoquinone-Loaded Soluplus®-Solutol® HS15 Mixed Micelles: Preparation, In Vitro Characterization, and Effect on the SH-SY5Y Cell Migration MOLECULES (2020) 25 : 0 - 0 DOI: 10.3390/molecules25204707
Vasarri M.; Barletta E.; Vinci S.; Ramazzotti M.; Francesconi A.; Manetti F.; Degl'Innocenti D. Annona cherimola miller fruit as a promising candidate against diabetic complications: An in vitro study and preliminary clinical results FOODS (2020) 9 : 1350 - 1366 DOI: 10.3390/foods9101350
Leri M.; Vasarri M.; Palazzi L.; Barletta E.; Nielsen E.; Bucciantini M.; Degl'Innocenti D. Maysin plays a protective role against α-Synuclein oligomers cytotoxicity by triggering autophagy activation FOOD AND CHEMICAL TOXICOLOGY (2020) 144 : 111626 - 111635 DOI: 10.1016/j.fct.2020.111626
Vasarri M.; Barletta E.; Ramazzotti M.; Degl'Innocenti D. In vitro anti-glycation activity of the marine plant Posidonia oceanica (L.) Delile JOURNAL OF ETHNOPHARMACOLOGY (2020) 259 : 112960 - 112960 DOI: 10.1016/j.jep.2020.112960
Vasarri M.; Leri M.; Barletta E.; Ramazzotti M.; Marzocchini R.; Degl'Innocenti D. Anti-inflammatory properties of the marine plant Posidonia oceanica (L.) Delile JOURNAL OF ETHNOPHARMACOLOGY (2020) 247 : 112252 - 112252 DOI: 10.1016/j.jep.2019.112252
Degl'Innocenti, Donatella; Ramazzotti, Matteo; Sarchielli, Erica; Monti, Daniela; Chevanne, Marta; Vannelli, Gabriella Barbara; Barletta, Emanuela Oxadiazon affects the expression and activity of aldehyde dehydrogenase and acylphosphatase in human striatal precursor cells: a possible role in neurotoxicity TOXICOLOGY (2019) 411 : 110 - 121 DOI: 10.1016/j.tox.2018.10.021
Vieri Piazzini, Marzia Vasarri, Donatella Degl’Innocenti , Asia Guastini, Emanuela Barletta , Maria Cristina Salvatici, Maria Camilla Bergonzi Comparison of Chitosan Nanoparticles and Soluplus Micelles to Optimize the Bioactivity of Posidonia oceanica Extract on Human Neuroblastoma Cell Migration PHARMACEUTICS (2019) : 0 - 0 DOI: 10.3390/pharmaceutics11120655
Leri, Manuela; Ramazzotti, Matteo; Vasarri, Marzia; Peri, Sara; Barletta, Emanuela; Pretti, Carlo; Degl’Innocenti, Donatella Bioactive Compounds from Posidonia oceanica (L.) Delile Impair Malignant Cell Migration through Autophagy Modulation MARINE DRUGS (2018) 16 : 137 - 152 DOI: 10.3390/md16040137
Previous research experiences From the beginning of her research career Dr. Barletta has focused her attention on exploring the molecular mechanisms of cell adhesion and cell differentiation induced by specific adhesive substratum in normal and tumor cells. Her studies were centered on adhesive interactions between specific cell-surface molecules such as gangliosides, integrins, and heparan sulfates with adhesive proteins such as fibronectin, vitronectin and platelet factor 4 (PF4). Moreover, she focused her attention on the relationship between cell differentiation and invasive potential through extracellular matrix components. For this purpose she studied the effect of differentiating agents such as retinoic acid, platelet activatin factor (PAF), and neurotrophins CNTF (Ciliary Neurotrophic Factor) and BDNF (Brain Derived Neurotophic Factor) on differentiation and invasiveness of neuroblastoma cells through reconstituted membranes (Matrigel). In the last few years, Dr. Barletta has explored the molecular mechanisms of endothelial cell differentiation process. Indeed, endothelial differentiation requires modulation of adhesive properties and secretion of extracellular matrix degrading enzymes such as urokinase plasminogen activator (uPA). In this study she has revealed that basic fibroblastic growth factor (bFGF) upregulates uPA gene expression and that this effect is mediated by poly(ADP-ribose) polymerase (PARP) through activation of a mitogen-activated protein kinase pathway . Dr. Barletta during her research career has studied the role of mutationally activated ras oncogenes and occupational exposure in human acute myeloid leukemia (AML). In particular, she found in 111 AML cases a positive association between a priori at risk jobs and ras mutations.
Main scientific contributions
- Oxadiazon affects the expression and activity of aldehyde dehydrogenase and acylphosphatase in human striatal precursor cells: A possible role in neurotoxicity
- Platelet activating factor inhibits the expression of matrix metalloproteinases and affects invasiveness and differentiation in a system of human neuroblastoma clones
- Inverse relationship between invasiveness and differentiative capacity in different human neuroblastoma cell lines
- Integrin-mediated neurite outgrowth in neuroblastoma cells depends on the activation of potassium channels
- Ras gene mutations in patients with acute myeloid leukaemia and exposure to chemical agents
- Expression of cytokines and chemokine receptors in the cutaneous lesions of erythema multiforme and Stevens–Johnson syndrome/toxic epidermal necrolysis
Dr. Marzia Caproni, MD PhD, Adjunct professor, University of Florence; Director SOS Skin Immunopathology and Rare Dermatological Diseases Unit ASF Florence; 1st Dermatological Clinic ASF; Department of Medical and Surgical Critical Care, Section of Dermatology, University of Florence.