Gruppo Fambrini

Research Team’s name: Gynecologic Oncology

Coordinator Prof. Massimiliano Fambrini (Associate Professor of Ob/GYN, MED/40)

Personal Data:

Date and place of birth: Lucca (Italy), 15/02/1972


University of Florence, School of Medicine, M.D. (110/110 lode), 1997

University of Florence, School of Medicine, Specialisation in Gynecology and Obstetrics (70/70 lode), 2003

Physician, Careggi University Hospital, Florence, 2004-2007

University of Florence, Associate Research in Gynecology and Obstetrics, 2007-2011

University of Florence, Associated Professor in Gynecology and Obstetrics, 2011 – today

Director of Postgraduate School in Gynecology and Obstetrics, 2013-2017

Coordinator Of Multisciplinary Oncologic Team for Gynecological Cancer (Careggi University Hospital – Florence)

Member of the Scientific Board of the Doctorate/Phd Program in Biomedical Sciences (University of Florence)

Member of the following Scientific Societies:

SEGI (Società Endoscopia Ginecologica Italiana)

SIGO (Società Italiana Ginecologia e Ostetricia)

AGUI (Associazione Ginecologi Universitari Italiana)

ESGO (European Society Gynecologic Oncology)


Member of editorial board of the following Journals

Journal of Endometriosis and Pelvic Pain Disorders (


International Journal of Molecular Sciences (Special Issue ”Endometrial Cancer Overview: Molecular Biology and Its Potential Clinical Application”


Research Team:

Flavia Sorbi (Firenze, 17/11/1985) – Researcher MED/40 University of Florence

Francesca Malentacchi (Prato, 23/04/1976) – PhD, Biologist – University of Florence

Serena Pillozzi (Firenze, 02/01/1974) – PhD, Biologist

Cecilia Bussani (Genova, 23/03/1959) – PhD, Biologist


Current research interest

Mutational gene panels and their prognostic role of endometrioid endometrial cancer

New biomarkers as liquid biopsy for relapse of endometrial cancer patients

Mutation profile of PIK3CA/PTEN genes (PI3K pathway) in Grade 3 endometrioid endometrial cancer

Mutational gene panels and their prognostic role in uterine sarcomas

Bioelectrical properties of ovarian cancer cells

Detection of HPV infection in patients with cervical cancer (setting and comparison of two methodologies – HC2 by Qiagen and Linear array by Roche in cervical samples and urine)

Methylation profile of HOXA9 and HOXA 10 in gynecological cancer (evaluation of methylation profile of HOXA9 and HOXA10 in ovarian and endometrial cancers)

Evaluation of sexual disfunction in BRCA carriers

LH-hCG receptor and endometrial carcinoma (evaluation of LHR in spread of endometrial carcinoma in tissues and blood samples)


 Key words

Endometrial cancer, ovarian cancer, cervical cancer, vulvar cancer, fertility sparing surgery, prognosis, liquid biopsy, NGS, LH-hCG receptor


Current/recent sources of funding

ECRF (Ente Cassa Risparmio Firenze) 2012, 2013, 2016, 2017, 2018

Istituto Virologia Bartolomei Grant 2017

Ricerca Finalizzata Ministero della Salute GRF 2011


10 best pubblications of the last 5 years


1: COVIDSurg Collaborative. Delaying surgery for patients with a previous SARS-

CoV-2 infection. Br J Surg. 2020 Nov;107(12)


2: Meattini I, Marrazzo L, Saieva C, Desideri I, Scotti V, Simontacchi G, Bonomo

P, Greto D, Mangoni M, Scoccianti S, Lucidi S, Paoletti L, Fambrini M, Bernini

M, Sanchez L, Orzalesi L, Nori J, Bianchi S, Pallotta S, Livi L. Accelerated

Partial-Breast Irradiation Compared With Whole-Breast Irradiation for Early

Breast Cancer: Long-Term Results of the Randomized Phase III APBI-IMRT-Florence

Trial. J Clin Oncol. 2020 Dec 10;38(35):4175-4183


3: Malentacchi F, Turrini I, Zepponi F, Fantappiè G, Sorbi F, Antonuzzo L,

Fambrini M, Noci I, Pillozzi S. Mutational profile in circulating tumor DNA in a

patient affected by low-risk endometrial cancer: predictable tool of relapse?

Anticancer Drugs. 2020 Nov;31(10):1091-1095


4: Malentacchi F, Turrini I, Sorbi F, Projetto E, Castiglione F, Fambrini M,

Petraglia F, Pillozzi S, Noci I. Pilot investigation of the mutation profile of

PIK3CA/PTEN genes (PI3K pathway) in grade 3 endometrial cancer. Oncol Rep. 2019



5: Sorbi F, Projetto E, Turrini I, Baroni G, Pillozzi S, Ghizzoni V, Vergoni F,

Castiglione F, Malentacchi F, Fambrini M, Noci I. Luteinizing Hormone/Human

Chorionic Gonadotropin Receptor Immunohistochemical Score Associated with Poor

Prognosis in Endometrial Cancer Patients. Biomed Res Int. 2018 Apr



6: Pieralli A, Bianchi C, Auzzi N, Fallani MG, Bussani C, Fambrini M, Cariti G,

Scarselli G, Petraglia F, Ghelardi A. Indication of prophylactic vaccines as a

tool for secondary prevention in HPV-linked disease. Arch Gynecol Obstet. 2018



7: Cunnea P, Gorgy T, Petkos K, Gowers SAN, Lu H, Morera C, Wu W, Lawton P, NixonK, Leong CL, Sorbi F, Domenici L, Paterson A, Curry E, Gabra H, Boutelle MG, Drakakis EM,

Fotopoulou C. Clinical value of bioelectrical properties of cancerous tissue in advanced

epithelial ovarian cancer patients. Sci Rep. 2018 Oct 2;8(1):14695


8: Nasioudis D, Sisti G, Kanninen TT, Holcomb K, Di Tommaso M, Fambrini M,

Witkin SS. Epidemiology and outcomes of squamous ovarian carcinoma; a

population-based study. Gynecol Oncol. 2016 Apr;141(1):128-33.


9: Sisti A, Tassinari J, Nisi G, Grimaldi L, Sisti G, DI Tommaso M, Fambrini M.

Synchronous and Metachronous Malignancies After Malignant Struma Ovarii in the

SEER Database. In Vivo. 2016 09-10;30(5):713-6.


10: Meattini I, Saieva C, Meacci F, Scotti V, De Luca Cardillo C, Desideri I,

Baldazzi V, Mangoni M, Scoccianti S, Detti B, Simontacchi G, Nori J, Orzalesi L,

Sanchez L, Casella D, Bernini M, Fambrini M, Bianchi S, Livi L. Impact of age on

cytotoxic-induced ovarian failure in breast cancer treated with adjuvant

chemotherapy and triptorelin. Future Oncol. 2016 Mar;12(5):625-35.



Previeus research experiences

methylation  of HOXA genes in endometrial cancer and endometriosis

bioelectrical properties of ovarian cancer cells

mutational gene panels of endometrioid endometrial cancer

mutation profile of PIK3CA/PTEN genes (PI3K pathway) in Grade 3 endometrioid endometrial cancer

urine HPV testing and cervical cancer screening

Main scientific contributions


The GynO team has contributed in the fields of targeted therapies in advanced gynecological cancers, novel biomarkers for early diagnosis and follow-up in gynecological cancers, detection of HPV in urinary and cervical samples and prognostic significance, implementation in surgical practice for fertility sparing treatments in gynecology oncology.



Imperial College, Department of Surgery and Cancer, Prof Christina Fotopoulou on target therapies in gynecologic cancers, ultra-radical surgery, bioelectrical properties of ovarian cancers

Sapienza di Roma, Dept of Obstetrics and Gynecology, Prof Violante Donato: fertility preservation in cervical cancer, reconstructive surgery in vulvar cancer

Imperial College, Institute of Reproductive and Developmental Biology, Dr Srdjan Saso BSc MRCS MRCOG PhD on fertility-sparing surgery in ovarian cancer and on Fertility Treatment and Female-Specific Cancers


Ultimo aggiornamento



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